Jones C J, Brinton L A, Hamman R F, Stolley P D, Lehman H F, Levine R S, Mallin K
Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892.
Cancer Res. 1990 Jun 15;50(12):3657-62.
A case-control study of 293 patients with in situ cervical cancer and 801 community controls was conducted between 1982 and 1984 in five geographic areas in the United States. Relative risk (RR) was elevated among women reporting multiple sexual partners (RR for greater than or equal to 5 partners = 5.0), a history of an abnormal Papanicolaou smear (RR = 5.0), interval since last Papanicolaou smear (RR for greater than or equal to 10-year interval versus 0- to 2-year interval = 4.1), use of oral contraceptives (RR for greater than or equal to 10 years use = 1.4), a history of nonspecific genital infection (RR = 2.6), and smoking (RR for current smokers = 1.9). Risk was low among diaphragm users (RR for greater than 2 years use = 0.5). Neither age at first coitus nor number of births was predictive of risk of in situ disease. Comparisons between this analysis and risk factors previously identified for invasive cervical cancer in this same study indicate that the risk factors were quite similar.
1982年至1984年间，在美国五个地理区域对293例原位宫颈癌患者和801名社区对照者进行了一项病例对照研究。报告有多个性伴侣的女性（≥5个性伴侣的相对风险RR = 5.0）、巴氏涂片异常史（RR = 5.0）、自上次巴氏涂片以来的间隔时间（≥10年间隔与0至2年间隔相比RR = 4.1）、使用口服避孕药（≥10年使用RR = 1.4）、非特异性生殖器感染史（RR = 2.6）以及吸烟（当前吸烟者RR = 1.9）的女性，其相对风险升高。使用子宫托的女性风险较低（使用超过2年RR = 0.5）。首次性交年龄和生育次数均不能预测原位疾病风险。该分析与同一研究中先前确定的浸润性宫颈癌风险因素之间的比较表明，风险因素非常相似。
