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匹配荧光透视对比剂和增稠液处方的流变性能。

Matching the rheological properties of videofluoroscopic contrast agents and thickened liquid prescriptions.

机构信息

Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, Switzerland.

出版信息

Dysphagia. 2013 Jun;28(2):245-52. doi: 10.1007/s00455-012-9441-x. Epub 2013 Feb 14.

Abstract

In the treatment of oropharyngeal dysphagia, the link between diagnosis and prescription of thickened liquids that are safe to swallow is not always straightforward. Frequently, the capacity to objectively assess and quantify the rheological properties of diagnostic test fluids and to select "rheologically equivalent" dietary products is missing. Perhaps sometimes the importance of an objective comparison is not fully appreciated because two liquids seem reasonably similar in a subjective comparison (e.g., flow from a spoon). The present study deals with some of these issues. Shear viscosity measurements were used to characterize the flow behavior of videofluoroscopic contrast agents and of thickened fluids prepared with commercial thickening agents. Effects of time and composition of the different fluids were analyzed regarding shear-rate-dependent viscosity. Nearly all materials tested showed a pronounced dependence of viscosity with shear rate ("shear thinning"). Results confirm that it is feasible (but not always straightforward) to "match" the viscosities of diagnostic fluids and thickened beverages if certain precautions are taken. For example, the time required to reach final viscosity levels can be significant for some thickeners, particularly when used with liquids containing contrast agents. It is recommend to use only diagnostic materials and thickening agents for which reliable viscosity data are available.

摘要

在治疗口咽吞咽困难时,诊断和处方安全吞咽的增稠液之间的联系并不总是直接的。通常,缺乏客观评估和量化诊断测试液流变性的能力,也无法选择“流变等效”的饮食产品。也许有时人们并没有充分认识到客观比较的重要性,因为在主观比较中,两种液体看起来相当相似(例如,从汤匙中流出)。本研究涉及其中的一些问题。使用剪切粘度测量来描述荧光透视对比剂和用商业增稠剂制备的增稠液的流动行为。分析了不同液体的时间和组成对剪切速率相关粘度的影响。几乎所有测试的材料都表现出与剪切率相关的粘度明显依赖性(“剪切稀化”)。结果证实,如果采取某些预防措施,“匹配”诊断液和增稠饮料的粘度是可行的(但并不总是那么简单)。例如,对于某些增稠剂,特别是当它们与含有对比剂的液体一起使用时,达到最终粘度水平所需的时间可能会很长。建议仅使用具有可靠粘度数据的诊断材料和增稠剂。

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