Department of General Practice, Erasmus MC, University Medical Centre Rotterdam, Room GK 1048, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Eur J Nutr. 2014 Feb;53(1):95-104. doi: 10.1007/s00394-013-0505-y. Epub 2013 Feb 22.
Weight loss interventions have been studied extensively, but methodological limitations negatively affecting applicability in everyday clinical practice are a very common problem in these studies. Despite the fact that obesity is treated mostly in a primary care setting, studies that investigate weight loss interventions in a primary care setting are scarce. Our objective was to assess the effectiveness of a tailor-made weight loss intervention in achieving a clinically significant weight loss in overweight (BMI ≥ 27 kg/m²) women aged 50-60 years in a primary care setting.
As part of a randomized controlled trial on the effects of a tailor-made weight loss intervention and oral glucosamine sulphate on the incidence of osteoarthritis of the knee in 407 overweight women aged 50-60 years, we analysed the effectiveness of the weight loss intervention in achieving clinically relevant weight loss.
At baseline, the mean body weight for all participants was 88.7 ± 13.2 kg, and the mean BMI was 32.4 ± 4.3 kg/m². The percentage of participants that lost ≥5 kg or 5 % of their baseline body weight was 14.8 versus 6.3 % (p = 0.012) at 6 months for the intervention group and the control group, respectively. At 12 months, this was 18.7 versus 14.9 % (p = 0.027). Mean weight gain at 6 months was -0.9 versus 0.9 kg (p < 0.001) for the intervention group and the control group, respectively. At 12 months, this was -0.6 versus 0.6 kg (p = 0.01). At 30 months of follow-up, no significant differences were found between both groups.
This weight loss intervention, which, at short notice, is easily applicable in everyday clinical practice, is effective in achieving clinically significant weight loss in overweight women aged 50-60 over a 12-month period. Long-term weight loss maintenance, however, occurred only marginally. Magnitude of the effect is comparable to that achieved in many other more intensive weight loss interventions.
尽管肥胖症主要在初级保健环境中进行治疗，但在初级保健环境中研究减肥干预措施的研究却很少。我们的目的是评估一种量身定制的减肥干预措施在超重（BMI≥27kg/m²）50-60 岁女性中实现临床显著减肥的效果。
作为一项针对量身定制的减肥干预措施和口服葡萄糖胺硫酸盐对 407 名 50-60 岁超重女性膝关节骨关节炎发病率影响的随机对照试验的一部分，我们分析了减肥干预措施在实现临床相关减肥方面的效果。
在基线时，所有参与者的平均体重为 88.7±13.2kg，平均 BMI 为 32.4±4.3kg/m²。干预组和对照组分别有 14.8%和 6.3%（p=0.012）的参与者在 6 个月时体重减轻≥5kg 或基线体重的 5%，12 个月时这一比例分别为 18.7%和 14.9%（p=0.027）。干预组和对照组在 6 个月时的平均体重增加分别为-0.9kg 和 0.9kg（p<0.001），12 个月时分别为-0.6kg 和 0.6kg（p=0.01）。在 30 个月的随访中，两组之间没有发现显著差异。
这种减肥干预措施，在短期内，在日常临床实践中很容易应用，在 12 个月内对 50-60 岁超重女性有效实现临床显著减肥。然而，长期减肥维持仅略有增加。其效果的幅度与许多其他更密集的减肥干预措施相当。
