Unit of Biology and Genetics of Movement, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 15, 00135 Rome, Italy.
Unit of Physical Exercise and Sport Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 15, 00135 Rome, Italy.
Int J Environ Res Public Health. 2021 Sep 18;18(18):9834. doi: 10.3390/ijerph18189834.
Breast cancer (BC) is the most commonly diagnosed cancer among women worldwide and the most common cause of cancer-related death. To date, it is still a challenge to estimate the magnitude of the clinical impact of physical activity () on those parameters producing significative changes in future BC risk and disease progression. However, studies conducted in recent years highlight the role of not only as a protective factor for the development of ER+ breast cancer but, more generally, as a useful tool in the management of BC treatment as an adjuvant to traditional therapies. In this review, we focused our attention on data obtained from human studies analyzing, at each level of disease prevention (i.e., primary, secondary, tertiary and quaternary), the positive impact of /exercise in ER+ BC, a subtype representing approximately 70% of all BC diagnoses. Moreover, given the importance of estrogen receptors and body composition (i.e., adipose tissue) in this subtype of BC, an overview of their role will also be made throughout this review.
乳腺癌 (BC) 是全球女性最常见的癌症，也是癌症相关死亡的最常见原因。迄今为止，要估计体育活动对未来 BC 风险和疾病进展产生显著变化的参数的临床影响程度仍然是一个挑战。然而，近年来进行的研究强调了的作用，不仅作为 ER+ 乳腺癌发生的保护因素，而且更普遍地作为 BC 治疗管理的有用工具，作为传统疗法的辅助手段。在这篇综述中，我们将注意力集中在分析人类研究中获得的数据上，这些研究在疾病预防的各个层面（即一级、二级、三级和四级）分析了在 ER+BC 中的积极影响，这是一种约占所有 BC 诊断的 70%的亚型。此外，鉴于雌激素受体和身体成分（即脂肪组织）在这种 BC 亚型中的重要性，本综述还将概述它们的作用。
