Natalucci Valentina, Lucertini Francesco, Vallorani Luciana, Brandi Giorgio, Marchegiani Manuela, Pistelli Mirco, Berardi Rossana, Ceravolo Maria Gabriella, Barbieri Elena, Capecci Marianna
Department of Biomolecular Science, University of Urbino Carlo Bo, Via I. Maggetti, 26, 61029, Urbino, Italy.
Neuro-rehabilitation Clinic, Breast Unit, Department of Neurological Science, University Hospital "Ospedali Riuniti di Ancona", Via Conca, 71, 60126, Ancona, Italy.
Heliyon. 2021 Oct 27;7(11):e08252. doi: 10.1016/j.heliyon.2021.e08252. eCollection 2021 Nov.
Given the benefits of physical activity for breast cancer survivals, this pilot study aims to assess the feasibility of the MOTIVE program at achieving and maintaining the recommended physical activity level in women diagnosed and treated breast cancer, over 16 weeks. We conduct a pilot-controlled study of 20 women diagnosed with breast cancer stage I, II or IIIa. In this study, women of Intervention Arm (n = 10) received the MOTIVE program. This group was compared to women of Control Arm (n = 10) who received only counselling. Health-related fitness measures, and quality of life were assessed at baseline (t0) and after 4 (t1), 8 (t2) and 16 (t3) weeks. Intervention Arm women reached the recommended physical activity guidelines at t1 and t2 (eff.size = 1.9 [1.0-3.1]), and 90% continued to be active, autonomously, at t3 (eff.size = 1.12 [0.21-2.12]). Intervention Arm participants' arm strength, fitness levels and quality of life also improved over time. No significant improvements in outcome measures were observed in Control Arm participants. These results are encouraging and suggest that the MOTIVE program may be a viable, well tolerated and effective option to help breast cancer women reaching a stable physical activity level over time, which meets prevention-related goals.
鉴于体育活动对乳腺癌幸存者有益，这项试点研究旨在评估MOTIVE计划在16周内，使确诊并接受治疗的乳腺癌女性达到并维持推荐身体活动水平的可行性。我们对20名确诊为I期、II期或IIIa期乳腺癌的女性进行了一项试点对照研究。在本研究中，干预组（n = 10）的女性接受了MOTIVE计划。该组与仅接受咨询的对照组（n = 10）女性进行比较。在基线（t0）以及4周（t1）、8周（t2）和16周（t3）后评估与健康相关的体能指标和生活质量。干预组女性在t1和t2时达到了推荐的身体活动指南（效应量=1.9 [1.0 - 3.1]），并且在t3时90%的女性继续自主保持活跃（效应量=1.12 [0.21 - 2.12]）。干预组参与者的手臂力量、体能水平和生活质量也随时间得到改善。对照组参与者在结果指标上未观察到显著改善。这些结果令人鼓舞，表明MOTIVE计划可能是一种可行、耐受性良好且有效的选择，有助于乳腺癌女性随着时间推移达到稳定的身体活动水平，这符合预防相关目标。
