• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于纳米线的电极，用于大脑中的急性活体神经记录。

Nanowire-based electrode for acute in vivo neural recordings in the brain.

机构信息

Division of Solid State Physics and The Nanometer Structure Consortium, Lund University, Lund, Sweden.

出版信息

PLoS One. 2013;8(2):e56673. doi: 10.1371/journal.pone.0056673. Epub 2013 Feb 19.

DOI:10.1371/journal.pone.0056673
PMID:23431387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3576334/
Abstract

We present an electrode, based on structurally controlled nanowires, as a first step towards developing a useful nanostructured device for neurophysiological measurements in vivo. The sensing part of the electrode is made of a metal film deposited on top of an array of epitaxially grown gallium phosphide nanowires. We achieved the first functional testing of the nanowire-based electrode by performing acute in vivo recordings in the rat cerebral cortex and withstanding multiple brain implantations. Due to the controllable geometry of the nanowires, this type of electrode can be used as a model system for further analysis of the functional properties of nanostructured neuronal interfaces in vivo.

摘要

我们提出了一种基于结构控制纳米线的电极，作为开发用于体内神经生理学测量的有用纳米结构器件的第一步。电极的传感部分由沉积在砷化镓纳米线阵列顶部的金属膜制成。我们通过在大鼠大脑皮层进行急性体内记录并经受多次脑内植入来实现基于纳米线的电极的首次功能测试。由于纳米线的可控几何形状，这种类型的电极可用作体内纳米结构神经元界面功能特性的进一步分析的模型系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/cfb0afd0d9b2/pone.0056673.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/9c9281524a21/pone.0056673.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/77b1fd8d151c/pone.0056673.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/78c515c341a2/pone.0056673.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/f2580ad8e367/pone.0056673.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/8cdb017fef4b/pone.0056673.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/cfb0afd0d9b2/pone.0056673.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/9c9281524a21/pone.0056673.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/77b1fd8d151c/pone.0056673.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/78c515c341a2/pone.0056673.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/f2580ad8e367/pone.0056673.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/8cdb017fef4b/pone.0056673.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7096/3576334/cfb0afd0d9b2/pone.0056673.g006.jpg

相似文献

1
Nanowire-based electrode for acute in vivo neural recordings in the brain.基于纳米线的电极，用于大脑中的急性活体神经记录。
PLoS One. 2013;8(2):e56673. doi: 10.1371/journal.pone.0056673. Epub 2013 Feb 19.
2
Morphology of living cells cultured on nanowire arrays with varying nanowire densities and diameters.在具有不同纳米线密度和直径的纳米线阵列上培养的活细胞的形态。
Sci China Life Sci. 2018 Apr;61(4):427-435. doi: 10.1007/s11427-017-9264-2. Epub 2018 Apr 2.
3
Quantifying long-term microelectrode array functionality using chronic in vivo impedance testing.使用慢性体内阻抗测试来量化长期微电极阵列的功能。
J Neural Eng. 2012 Apr;9(2):026028. doi: 10.1088/1741-2560/9/2/026028. Epub 2012 Mar 23.
4
Impact of degradable nanowires on long-term brain tissue responses.可降解纳米线对脑组织长期反应的影响。
J Nanobiotechnology. 2016 Aug 9;14(1):64. doi: 10.1186/s12951-016-0216-7.
5
Soft tissue reactions evoked by implanted gallium phosphide.植入磷化镓引起的软组织反应。
Biomaterials. 2008 Dec;29(35):4598-604. doi: 10.1016/j.biomaterials.2008.08.028. Epub 2008 Sep 17.
6
Neural circuits and temporal plasticity in hindlimb representation of rat primary somatosensory cortex: revisited by multi-electrode array on brain slices.大鼠初级体感皮层后肢代表区的神经回路和时间可塑性：脑片多电极阵列的再研究。
Neurosci Bull. 2010 Jun;26(3):175-87. doi: 10.1007/s12264-010-0308-6.
7
Neurite outgrowth and synaptophysin expression of postnatal CNS neurons on GaP nanowire arrays in long-term retinal cell culture.在长期视网膜细胞培养中，GaP 纳米线阵列上的出生后中枢神经系统神经元的神经突生长和突触小体蛋白表达。
Biomaterials. 2013 Jan;34(4):875-87. doi: 10.1016/j.biomaterials.2012.10.042. Epub 2012 Nov 3.
8
Feasibility of imaging evoked activity throughout the rat brain using electrical impedance tomography.使用电阻抗断层成像技术对大鼠全脑诱发电活动进行成像的可行性研究。
Neuroimage. 2018 Sep;178:1-10. doi: 10.1016/j.neuroimage.2018.05.022. Epub 2018 May 10.
9
Gallium phosphide nanowires as a substrate for cultured neurons.磷化镓纳米线作为培养神经元的基质。
Nano Lett. 2007 Oct;7(10):2960-5. doi: 10.1021/nl070728e. Epub 2007 Sep 19.
10
Raman spectroscopy and structure of crystalline gallium phosphide nanowires.磷化镓晶体纳米线的拉曼光谱与结构
J Nanosci Nanotechnol. 2003 Aug;3(4):335-9. doi: 10.1166/jnn.2003.208.

引用本文的文献

1
Interfacing with the Brain: How Nanotechnology Can Contribute.与大脑交互：纳米技术如何发挥作用。
ACS Nano. 2025 Mar 25;19(11):10630-10717. doi: 10.1021/acsnano.4c10525. Epub 2025 Mar 10.
2
Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.生物电子医学：从生物物理学到精准治疗的多学科路线图。
Front Integr Neurosci. 2024 Feb 19;18:1321872. doi: 10.3389/fnint.2024.1321872. eCollection 2024.
3
Recent Advancements in Graphene-Based Implantable Electrodes for Neural Recording/Stimulation.

本文引用的文献

1
Semiconductor nanowires: A platform for nanoscience and nanotechnology.半导体纳米线：纳米科学与纳米技术的一个平台。
MRS Bull. 2011 Dec 1;36(12):1052-1063. doi: 10.1557/mrs.2011.269.
2
Intracellular recording of action potentials by nanopillar electroporation.通过纳米柱电穿孔进行动作电位的细胞内记录。
Nat Nanotechnol. 2012 Feb 12;7(3):185-90. doi: 10.1038/nnano.2012.8.
3
Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits.垂直纳米线电极阵列作为一种可扩展的平台，用于与神经元回路进行细胞内接口。
基于石墨烯的可植入神经记录/刺激电极的最新进展。
Sensors (Basel). 2023 Dec 18;23(24):9911. doi: 10.3390/s23249911.
4
Proof of Concept for Sustainable Manufacturing of Neural Electrode Array for In Vivo Recording.用于体内记录的神经电极阵列可持续制造的概念验证。
Biosensors (Basel). 2023 Feb 16;13(2):280. doi: 10.3390/bios13020280.
5
Considerations and recent advances in nanoscale interfaces with neuronal and cardiac networks.与神经元和心脏网络的纳米级界面的考量与最新进展。
Appl Phys Rev. 2021 Dec;8(4):041317. doi: 10.1063/5.0052666.
6
Biomedical Implants with Charge-Transfer Monitoring and Regulating Abilities.具有电荷转移监测和调节功能的生物医学植入物。
Adv Sci (Weinh). 2021 Aug;8(16):e2004393. doi: 10.1002/advs.202004393. Epub 2021 Jun 24.
7
Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation.神经-纳米界面：利用纳米涂层和纳米颗粒实现下一代电生理记录、神经刺激和生化调节。
Adv Funct Mater. 2018 Mar 21;28(12). doi: 10.1002/adfm.201700239. Epub 2017 Jun 7.
8
Nanowired Bioelectric Interfaces.纳米生物电界面。
Chem Rev. 2019 Aug 14;119(15):9136-9152. doi: 10.1021/acs.chemrev.8b00795. Epub 2019 Apr 17.
9
Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.利用纳米技术和神经科学的相互作用：为治疗中枢神经系统疾病开辟新途径。
Adv Drug Deliv Rev. 2019 Aug;148:181-203. doi: 10.1016/j.addr.2019.02.009. Epub 2019 Mar 4.
10
Advances in Nano Neuroscience: From Nanomaterials to Nanotools.纳米神经科学进展：从纳米材料到纳米工具
Front Neurosci. 2019 Jan 15;12:953. doi: 10.3389/fnins.2018.00953. eCollection 2018.
Nat Nanotechnol. 2012 Jan 10;7(3):180-4. doi: 10.1038/nnano.2011.249.
4
Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor.通过纳米尺度的场效应晶体管进行细胞内动作电位的细胞外记录。
Nat Nanotechnol. 2011 Dec 18;7(3):174-9. doi: 10.1038/nnano.2011.223.
5
Biocompatible multichannel electrodes for long-term neurophysiological studies and clinical therapy--novel concepts and design.用于长期神经生理研究和临床治疗的生物相容多通道电极——新概念和设计。
Prog Brain Res. 2011;194:61-70. doi: 10.1016/B978-0-444-53815-4.00017-0.
6
Design and Implementation of Functional Nanoelectronic Interfaces With Biomolecules, Cells, and Tissue Using Nanowire Device Arrays.使用纳米线器件阵列设计并实现与生物分子、细胞及组织的功能性纳米电子接口。
IEEE Trans Nanotechnol. 2010 May;9(3):269-280. doi: 10.1109/TNANO.2009.2031807.
7
Axonal guidance on patterned free-standing nanowire surfaces.图案化自支撑纳米线表面上的轴突导向
Nanotechnology. 2008 Aug 27;19(34):345101. doi: 10.1088/0957-4484/19/34/345101. Epub 2008 Jul 15.
8
Nanostructured gold microelectrodes for extracellular recording from electrogenic cells.用于从发电细胞进行细胞外记录的纳米结构金微电极。
Nanotechnology. 2011 Jul 1;22(26):265104. doi: 10.1088/0957-4484/22/26/265104. Epub 2011 May 18.
9
Superior electrochemical performance of carbon nanotubes directly grown on sharp microelectrodes.在尖锐微电极上直接生长的碳纳米管具有优异的电化学性能。
ACS Nano. 2011 Mar 22;5(3):2206-14. doi: 10.1021/nn103445d. Epub 2011 Feb 22.
10
Intact mammalian cell function on semiconductor nanowire arrays: new perspectives for cell-based biosensing.半导体纳米线阵列上完整的哺乳动物细胞功能：用于基于细胞的生物传感的新视角。
Small. 2011 Mar 7;7(5):640-7. doi: 10.1002/smll.201001642. Epub 2011 Feb 2.