Department of Applied Chemistry, College of Engineering, Kyungpook National University, Taegu 702-701, South Korea.
Curr Top Med Chem. 2013;13(4):422-33. doi: 10.2174/1568026611313040003.
Potentials of hydrophilic and biocompatible ligand coated gadolinium oxide nanoparticles as multimodal imaging agents, drug carriers, and therapeutic agents are reviewed. First of all, they can be used as advanced T1 magnetic resonance imaging (MRI) contrast agents because they have r1 larger than those of Gd(III)-chelates due to a high density of Gd(III) per nanoparticle. They can be further functionalized by conjugating other imaging agents such as fluorescent imaging (FI), X-ray computed tomography (CT), positron emission tomography (PET), and single photon emission tomography (SPECT) agents. They can be also useful for drug carriers through morphology modifications. They themselves are also potential CT and ultrasound imaging (USI) contrast and thermal neutron capture therapeutic (NCT) agents, which are superior to commercial iodine compounds, air-filled albumin microspheres, and boron ((10)B) compounds, respectively. They, when conjugated with targeting agents such as antibodies and peptides, will provide enhanced images and be also very useful for diagnosis and therapy of diseases (so called theragnosis).
综述了亲水性和生物相容性配体包覆的氧化钆纳米粒子作为多模态成像剂、药物载体和治疗剂的潜力。首先，由于每个纳米粒子中含有高密度的 Gd(III)，它们可用作先进的 T1 磁共振成像（MRI）造影剂，具有比 Gd(III)-螯合物更大的 r1。通过与其他成像剂（如荧光成像（FI）、X 射线计算机断层扫描（CT）、正电子发射断层扫描（PET）和单光子发射断层扫描（SPECT））结合，可以进一步对其进行功能化。通过形态修饰，它们也可作为药物载体使用。它们本身也是潜在的 CT 和超声成像（USI）造影剂和热中子俘获治疗（NCT）剂，分别优于商业碘化合物、充空气白蛋白微球和硼（(10)B）化合物。当与抗体和肽等靶向剂结合时，它们将提供增强的图像，并且对于疾病的诊断和治疗（所谓的治疗学）也非常有用。
