Yamazaki Masashi, Sakuma Tsuyoshi, Kato Kei, Furuya Takeo, Koda Masao
Chiba University Graduate School of Medicine, Chiba, Japan.
J Spinal Cord Med. 2013 Jan;36(1):40-3. doi: 10.1179/2045772312Y.0000000023.
A clinical trial was conducted to evaluate the safety and efficacy of neuroprotective therapy using granulocyte colony-stimulating factor (G-CSF) for patients with worsening symptoms of compression myelopathy. During this trial, we found that neuropathic pain associated with thoracic myelopathy was dramatically reduced after G-CSF administration in two cases.
A 32-year-old man with compression of the spinal cord at levels T7-T10 complained of spastic gait associated with spontaneous severe pain from his back to his chest. G-CSF 10 µg/kg/day was administered for 5 consecutive days; his pain was reduced 1 day after the initial G-CSF administration. One month after administration, he underwent spinal fusion surgery for decompression of the spinal cord. Six months after G-CSF administration, he showed recovery from myelopathy and no recurrence of pain. A 68-year-old man with spastic gait and bilateral thigh pain caused by ossified ligamentum flavum at T11-T12 was treated with G-CSF 10 µg/kg/day for 5 days; his pain was reduced 1 day after initial administration. One month later, he underwent a T10-T12 laminectomy. Three months after G-CSF administration, his thigh pain began to attenuate. At 6 months after administration, he showed recovery from myelopathy, and his pain was still improved compared with that before administration.
G-CSF may have a therapeutic effect on spinal neuropathic pain.
开展了一项临床试验，以评估使用粒细胞集落刺激因子（G-CSF）对脊髓型颈椎病症状加重患者进行神经保护治疗的安全性和有效性。在该试验中，我们发现两例患者在给予G-CSF后，与胸椎脊髓病相关的神经性疼痛显著减轻。
一名32岁男性，脊髓在T7-T10水平受压，主诉有痉挛性步态，并伴有从背部至胸部的自发性剧痛。连续5天给予10μg/kg/天的G-CSF；首次给予G-CSF后1天，其疼痛减轻。给药1个月后，他接受了脊髓减压脊柱融合手术。给予G-CSF 6个月后，他的脊髓病症状有所恢复，且疼痛未复发。一名68岁男性，因T11-T12黄韧带骨化导致痉挛性步态和双侧大腿疼痛，接受了5天的10μg/kg/天G-CSF治疗；首次给药后1天，其疼痛减轻。1个月后，他接受了T10-T12椎板切除术。给予G-CSF 3个月后，他的大腿疼痛开始减轻。给药6个月后，他的脊髓病症状有所恢复，且与给药前相比，疼痛仍有所改善。
G-CSF可能对脊髓神经性疼痛具有治疗作用。
