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囊尾蚴性脑膜炎——一种恶性的神经囊尾蚴病形式,对吡喹酮反应不佳。

Cysticercal meningitis--a pernicious form of neurocysticercosis which responds poorly to praziquantel.

作者信息

Joubert J

机构信息

Department of Neurology, Medical University of Southern Africa, Pretoria.

出版信息

S Afr Med J. 1990 May 19;77(10):528-30.

PMID:2343353
Abstract

Chronic cysticercal meningitis was diagnosed in 6 of 260 cases of neurocysticercosis. Clinical features usually associated with meningitis, such as fever, cranial nerve palsies and nuchal rigidity, were absent and the diagnosis was reached because of persistently abnormal cerebrospinal fluid (CSF) associated with active neurocysticercosis on computed tomography. Other causes of chronic meningitis were excluded. Hydrocephalus, either obstructive or communicating, was present in all 6 patients. The results of medical treatment with praziquantel were poor and there was no improvement either clinically or in the CSF. Severe clinical sequelae, such as dementia, blindness and gait ataxia, were common despite protracted medical treatment and ventriculoperitoneal shunting.

摘要

在260例神经囊尾蚴病患者中,有6例被诊断为慢性囊尾蚴性脑膜炎。通常与脑膜炎相关的临床特征,如发热、颅神经麻痹和颈项强直并不存在,诊断是因为计算机断层扫描显示脑脊液(CSF)持续异常且伴有活动性神经囊尾蚴病。其他慢性脑膜炎的病因已被排除。所有6例患者均存在梗阻性或交通性脑积水。吡喹酮药物治疗效果不佳,临床症状和脑脊液均无改善。尽管进行了长期的药物治疗和脑室腹腔分流术,但严重的临床后遗症,如痴呆、失明和步态共济失调仍很常见。

相似文献

1
Cysticercal meningitis--a pernicious form of neurocysticercosis which responds poorly to praziquantel.囊尾蚴性脑膜炎——一种恶性的神经囊尾蚴病形式,对吡喹酮反应不佳。
S Afr Med J. 1990 May 19;77(10):528-30.
2
Treatment of neurocysticercosis.神经囊尾蚴病的治疗
S Afr Med J. 1990 Jan 6;77(1):27-30.
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Acute cysticercal meningitis in children: response to praziquantel.儿童急性囊尾蚴性脑膜炎:对吡喹酮的反应
Ann Trop Paediatr. 1997 Mar;17(1):9-13. doi: 10.1080/02724936.1997.11747856.
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Praziquantel in the treatment of neurocysticercosis: long-term follow-up.吡喹酮治疗神经囊尾蚴病:长期随访
Neurology. 1985 May;35(5):752-5. doi: 10.1212/wnl.35.5.752.
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Racemose neurocysticercosis after chronic meningitis: effect of medical treatment.慢性脑膜炎后蔓状神经囊尾蚴病:药物治疗的效果
Clin Neurol Neurosurg. 1995 Feb;97(1):50-4. doi: 10.1016/0303-8467(94)00061-a.
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[Acute meningitis with cerebrospinal fluid eosinophilia: neurocysticercosis].
Psychiatr Neurol Med Psychol (Leipz). 1989 Sep;41(9):545-9.
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Neurocysticercosis: surgical and medical management with praziquantel.神经囊尾蚴病:使用吡喹酮的手术及药物治疗
Neurosurgery. 1986 Apr;18(4):419-27. doi: 10.1227/00006123-198604000-00005.
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Rapid and complete resolution of giant cysticercal cysts after administration of praziquantel. A report of 4 cases.吡喹酮治疗后巨大囊尾蚴囊肿迅速完全消退。4例报告。
S Afr Med J. 1990 Feb 3;77(3):154-7.

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Severe cysticercal meningitis: clinical and imaging characteristics.严重囊虫性脑膜炎:临床和影像学特征。
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Acute cysticercal meningitis--missed diagnosis.急性囊尾蚴性脑膜炎——漏诊
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Multilevel intramedullary spinal neurocysticercosis with eosinophilic meningitis.伴有嗜酸性脑膜炎的多级脊髓内神经囊尾蚴病
Arch Neurol. 2004 May;61(5):770-2. doi: 10.1001/archneur.61.5.770.