人脑半球的离体磁共振容积测量。
Ex vivo MR volumetry of human brain hemispheres.
机构信息
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
出版信息
Magn Reson Med. 2014 Jan;71(1):364-74. doi: 10.1002/mrm.24661. Epub 2013 Feb 25.
PURPOSE
The aims of this work were to (a) develop an approach for ex vivo MR volumetry of human brain hemispheres that does not contaminate the results of histopathological examination, (b) longitudinally assess regional brain volumes postmortem, and (c) investigate the relationship between MR volumetric measurements performed in vivo and ex vivo.
METHODS
An approach for ex vivo MR volumetry of human brain hemispheres was developed. Five hemispheres from elderly subjects were imaged ex vivo longitudinally. All datasets were segmented. The longitudinal behavior of volumes measured ex vivo was assessed. The relationship between in vivo and ex vivo volumetric measurements was investigated in seven elderly subjects imaged both antemortem and postmortem.
RESULTS
This approach for ex vivo MR volumetry did not contaminate the results of histopathological examination. For a period of 6 months postmortem, within-subject volume variation across time points was substantially smaller than intersubject volume variation. A close linear correspondence was detected between in vivo and ex vivo volumetric measurements.
CONCLUSION
Regional brain volumes measured with this approach for ex vivo MR volumetry remain relatively unchanged for a period of 6 months postmortem. Furthermore, the linear relationship between in vivo and ex vivo MR volumetric measurements suggests that this approach captures information linked to antemortem macrostructural brain characteristics.
目的
本研究旨在（a）开发一种不会污染组织病理学检查结果的人脑半球离体磁共振容积测量方法，（b）对死后的脑区容积进行纵向评估，以及（c）研究体内和离体磁共振容积测量之间的关系。
方法
开发了一种人脑半球离体磁共振容积测量方法。对 5 例老年受试者的半球进行离体纵向成像。所有数据集均进行分割。评估了离体测量的体积的纵向变化。在 7 例生前和死后均进行成像的老年受试者中，研究了体内和离体容积测量之间的关系。
结果
该离体磁共振容积测量方法不会污染组织病理学检查结果。在死后 6 个月内，各时间点的受试者内体积变化明显小于受试者间体积变化。在体内和离体容积测量之间检测到了密切的线性对应关系。
结论
在死后 6 个月内，使用该方法测量的脑区体积相对保持不变。此外，体内和离体磁共振容积测量之间的线性关系表明，该方法可以捕获与生前宏观结构脑特征相关的信息。
Zotero 插件