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医护人员在呼吸道合胞病毒感染治疗期间接触利巴韦林的情况。

Exposure of health care workers to ribavirin during therapy for respiratory syncytial virus infections.

作者信息

Bradley J S, Connor J D, Compogiannis L S, Eiger L L

机构信息

Department of Pediatrics, University of California, San Diego, La Jolla 92093.

出版信息

Antimicrob Agents Chemother. 1990 Apr;34(4):668-70. doi: 10.1128/AAC.34.4.668.

DOI:10.1128/AAC.34.4.668
PMID:2344173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171665/
Abstract

Health care workers (HCW) are exposed to ribavirin aerosol during therapy of infants with respiratory syncytial virus infections. To assess the degree of HCW exposure, we analyzed air samples from patient rooms and HCW personal breathing zones during ribavirin aerosol delivery by ventilator (two samples), oxygen hood (two samples), and a new vacuum exhaust hood (four samples). HCW exposure to ribavirin during aerosol delivery by ventilator or vacuum exhaust hood system was substantially lower than HCW exposure during aerosol delivery by oxygen hood in rooms with adequate ventilation.

摘要

医护人员在治疗呼吸道合胞病毒感染的婴儿时会接触到利巴韦林气雾剂。为评估医护人员的接触程度，我们分析了在使用呼吸机（两个样本）、氧气头罩（两个样本）和新型真空排气头罩（四个样本）进行利巴韦林气雾剂给药期间，病房和医护人员个人呼吸区域的空气样本。在通风良好的房间里，通过呼吸机或真空排气头罩系统进行气雾剂给药时医护人员接触利巴韦林的程度明显低于通过氧气头罩给药时医护人员的接触程度。

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本文引用的文献

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Sensitive radioimmunoassay for the broad-spectrum antiviral agent ribavirin.用于广谱抗病毒药物利巴韦林的灵敏放射免疫测定法。
Antimicrob Agents Chemother. 1983 Nov;24(5):696-701. doi: 10.1128/AAC.24.5.696.
2
Ribavirin aerosol treatment of bronchiolitis associated with respiratory syncytial virus infection in infants.利巴韦林气雾剂治疗婴儿呼吸道合胞病毒感染所致细支气管炎
Pediatrics. 1983 Nov;72(5):613-8.
3
Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. A randomized double-blind study.雾化吸入利巴韦林治疗呼吸道合胞病毒感染婴儿。一项随机双盲研究。
N Engl J Med. 1983 Jun 16;308(24):1443-7. doi: 10.1056/NEJM198306163082403.
4
Ribavirin treatment of respiratory syncytial viral infection in infants with underlying cardiopulmonary disease.利巴韦林治疗患有潜在心肺疾病婴儿的呼吸道合胞病毒感染。
JAMA. 1985 Dec 6;254(21):3047-51.
5
Environmental exposure of primary care personnel to ribavirin aerosol when supervising treatment of infants with respiratory syncytial virus infections.基层医疗人员在监督呼吸道合胞病毒感染婴儿治疗过程中接触利巴韦林气雾剂的环境暴露情况。
Antimicrob Agents Chemother. 1987 Jul;31(7):1143-6. doi: 10.1128/AAC.31.7.1143.
6
Aerosolized ribavirin treatment of respiratory syncytial virus infection in infants hospitalized during an epidemic.在一次流行期间，雾化利巴韦林治疗住院婴儿呼吸道合胞病毒感染。
Pediatr Infect Dis J. 1987 Feb;6(2):152-8. doi: 10.1097/00006454-198702000-00003.
7
Aerosolized ribavirin in the treatment of patients with respiratory syncytial virus disease.雾化利巴韦林治疗呼吸道合胞病毒疾病患者
Pediatr Infect Dis J. 1987 Feb;6(2):159-63. doi: 10.1097/00006454-198702000-00004.
8
Cross-species extrapolations and the biologic basis for safety factor determinations in developmental toxicology.跨物种外推与发育毒理学中安全系数确定的生物学基础。
Regul Toxicol Pharmacol. 1988 Mar;8(1):22-36. doi: 10.1016/0273-2300(88)90004-9.

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