利巴韦林对呼吸道合胞病毒的体内抑制作用。
In vivo inhibition of respiratory syncytial virus by ribavirin.
作者信息
Hruska J F, Morrow P E, Suffin S C, Douglas R G
出版信息
Antimicrob Agents Chemother. 1982 Jan;21(1):125-30. doi: 10.1128/AAC.21.1.125.
Abstract
Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.
摘要
利巴韦林使实验感染的棉鼠鼻甲和肺组织中的呼吸道合胞病毒数量减少了90%以上。无论是腹腔注射还是雾化给药，均可见此效果；然而，通过雾化途径给药时，在低得多的剂量下即可达到抗病毒效果。未见因该药物导致动物死亡的情况。
相似文献
1
In vivo inhibition of respiratory syncytial virus by ribavirin.利巴韦林对呼吸道合胞病毒的体内抑制作用。
Antimicrob Agents Chemother. 1982 Jan;21(1):125-30. doi: 10.1128/AAC.21.1.125.
2
Efficacy of high dose-short duration ribavirin aerosol in the treatment of respiratory syncytial virus infected cotton rats and influenza B virus infected mice.高剂量-短疗程利巴韦林气雾剂治疗呼吸道合胞病毒感染棉鼠和乙型流感病毒感染小鼠的疗效
Antiviral Res. 1987 May;7(4):211-20. doi: 10.1016/0166-3542(87)90029-5.
3
Ribavirin: beginning the blitz on respiratory viruses?利巴韦林：开启对呼吸道病毒的“闪电战”？
Pediatr Infect Dis. 1985 Nov-Dec;4(6):668-71. doi: 10.1097/00006454-198511000-00014.
4
Clinical review of ribavirin.利巴韦林的临床综述
Infect Control. 1987 May;8(5):215-8. doi: 10.1017/s0195941700065978.
5
Immunoglobulin administration and ribavirin therapy: efficacy in respiratory syncytial virus infection of the cotton rat.免疫球蛋白给药与利巴韦林治疗：对棉鼠呼吸道合胞病毒感染的疗效
Pediatr Res. 1987 Mar;21(3):270-4. doi: 10.1203/00006450-198703000-00013.
6
Vapors, viruses, and views. Ribavirin and respiratory syncytial virus.
Am J Dis Child. 1986 Apr;140(4):331-2. doi: 10.1001/archpedi.1986.02140180065025.
7
Ribavirin (Virazole).利巴韦林（病毒唑）。
Med Lett Drugs Ther. 1986 Apr 25;28(712):46-7.
8
Efficacy of ribavirin aerosol treatment for respiratory syncytial virus bronchiolitis in infants.利巴韦林气雾剂治疗婴儿呼吸道合胞病毒细支气管炎的疗效
J Int Med Res. 1987 Jul-Aug;15(4):227-33. doi: 10.1177/030006058701500406.
9
Ribavirin for influenza and respiratory syncytial virus infections.利巴韦林用于流感和呼吸道合胞病毒感染。
Lancet. 1983 Sep 3;2(8349):554-5.
10
Environmental exposure of primary care personnel to ribavirin aerosol when supervising treatment of infants with respiratory syncytial virus infections.基层医疗人员在监督呼吸道合胞病毒感染婴儿治疗过程中接触利巴韦林气雾剂的环境暴露情况。
Antimicrob Agents Chemother. 1987 Jul;31(7):1143-6. doi: 10.1128/AAC.31.7.1143.
引用本文的文献
1
Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis.人偏肺病毒管理与预后的临床见解及进展
Discoveries (Craiova). 2025 Mar 31;13(1):e204. doi: 10.15190/d.2025.3. eCollection 2025 Jan-Mar.
2
Antiviral agents against respiratory viruses.抗呼吸道病毒的抗病毒药物。
Clin Microbiol Newsl. 2001 Nov 1;23(21):163-170. doi: 10.1016/S0196-4399(01)89050-4. Epub 2001 Dec 24.
3
Chapter 8 Paramyxoviruses.第8章 副黏病毒
Perspect Med Virol. 1985;1:345-404. doi: 10.1016/S0168-7069(08)70016-8. Epub 2008 May 29.
4
Chapter 12. Antiviral Agents.第12章。抗病毒药物。
Annu Rep Med Chem. 1984;19:117-126. doi: 10.1016/S0065-7743(08)60688-0. Epub 2008 Apr 10.
5
Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.深入了解和控制呼吸道合胞病毒方面的进展：这么多年过去了，仍然让人感到疯狂。
Virus Res. 2011 Dec;162(1-2):80-99. doi: 10.1016/j.virusres.2011.09.020. Epub 2011 Sep 22.
6
Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model.棉鼠模型中呼吸道合胞病毒融合抑制剂的药代动力学-药效学研究。
Antimicrob Agents Chemother. 2010 Nov;54(11):4534-9. doi: 10.1128/AAC.00643-10. Epub 2010 Sep 7.
7
RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy.RNA干扰介导的呼吸道合胞病毒核衣壳沉默定义了一种有效的抗病毒策略。
Antimicrob Agents Chemother. 2009 Sep;53(9):3952-62. doi: 10.1128/AAC.00014-09. Epub 2009 Jun 8.
8
Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.利巴韦林与糖皮质激素治疗对人偏肺病毒感染小鼠模型的影响。
Antimicrob Agents Chemother. 2006 Feb;50(2):774-7. doi: 10.1128/AAC.50.2.774-777.2006.
9
Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection.呼吸道合胞病毒抑制剂在啮齿动物感染模型中的口服疗效。
Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. doi: 10.1128/AAC.48.7.2448-2454.2004.
10
Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice.RD3-0028气雾剂治疗免疫抑制小鼠呼吸道合胞病毒感染的疗效。
Antimicrob Agents Chemother. 1999 Apr;43(4):752-7. doi: 10.1128/AAC.43.4.752.
本文引用的文献
1
Effects of ribavirin on respiratory syncytial virus in vitro.利巴韦林对呼吸道合胞病毒的体外作用。
Antimicrob Agents Chemother. 1980 May;17(5):770-5. doi: 10.1128/AAC.17.5.770.
2
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.金刚烷胺和利巴韦林气雾剂对小鼠甲型和乙型流感感染的治疗作用
Antimicrob Agents Chemother. 1980 Apr;17(4):642-8. doi: 10.1128/AAC.17.4.642.
3
Suppression by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) of influenza virus-induced infections in mice.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对小鼠流感病毒诱导感染的抑制作用。
Antimicrob Agents Chemother. 1973 Apr;3(4):517-22. doi: 10.1128/AAC.3.4.517.
4
An evaluation of a new antiviral agent "virazole" against influenza virus infections.
Tohoku J Exp Med. 1973 Aug;110(4):405-6. doi: 10.1620/tjem.110.405.
5
Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺及相关核苷的设计、合成与广谱抗病毒活性
J Med Chem. 1972 Nov;15(11):1150-4. doi: 10.1021/jm00281a014.
6
Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.病毒唑的广谱抗病毒活性：1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺。
Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
7
In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对脱氧核糖核酸病毒和核糖核酸病毒的体外作用
Antimicrob Agents Chemother. 1973 Feb;3(2):235-41. doi: 10.1128/AAC.3.2.235.
8
The pathogenesis of respiratory syncytial virus infection in infant ferrets.婴儿雪貂呼吸道合胞病毒感染的发病机制。
Am J Pathol. 1976 Feb;82(2):339-52.
9
Treatment of influenza infection of mice by using rimantadine hydrochlorides by the aerosol and intraperitoneal routes.通过气溶胶和腹腔内途径使用盐酸金刚烷胺治疗小鼠流感感染。
Antimicrob Agents Chemother. 1975 Aug;8(2):154-8. doi: 10.1128/AAC.8.2.154.
10
Efficacy of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide against influenza virus infections in mice.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺对小鼠流感病毒感染的疗效。
Antimicrob Agents Chemother. 1975 May;7(5):582-6. doi: 10.1128/AAC.7.5.582.
Zotero 插件