Igarashi M
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
Asia Oceania J Obstet Gynaecol. 1990 Mar;16(1):1-12. doi: 10.1111/j.1447-0756.1990.tb00207.x.
In order to investigate the effect of the local direct action of danazol upon endometriosis, intravaginal and intrauterine application were tried. A vaginal danazol ring containing 2 g to 3.5 g danazol not only reduced both dysmenorrhea and the extent of pelvic endometriosis in all 35 infertile women, but also resulted in conception in 13 out of 35 infertile women while the vaginal ring was in place. Uterine adenomyosis usually fails to respond to oral danazol therapy, but an intrauterine device containing 175 mg of danazol was effective in reducing the size of the uterus and in inducing pregnancy in 66.6% cases. It is noteworthy that this vaginal or intrauterine danazol therapy did not inhibit ovulation, but still effected atrophy of endometriosis and aided in the establishment of pregnancy. These results clearly demonstrate that the main mode of action of danazol is its direct action on endometriotic cells.
为了研究达那唑局部直接作用于子宫内膜异位症的效果，尝试了经阴道和经子宫内给药。含2克至3.5克达那唑的阴道用达那唑环不仅减轻了所有35名不孕妇女的痛经和盆腔子宫内膜异位症的程度，而且在阴道环在位期间，35名不孕妇女中有13人受孕。子宫腺肌病通常对口服达那唑治疗无反应，但含175毫克达那唑的宫内节育器可有效缩小子宫大小，66.6%的病例可诱导妊娠。值得注意的是，这种阴道或子宫内达那唑治疗并不抑制排卵，但仍能使子宫内膜异位症萎缩并有助于妊娠的建立。这些结果清楚地表明，达那唑的主要作用方式是其对子宫内膜异位细胞的直接作用。
