Garavaglia Elisabetta, Audrey Serafini, Annalisa Inversetti, Stefano Ferrari, Iacopo Tandoi, Laura Corti, Massimo Candiani
Department of Obstetrics and Gynaecology, IRCCS San Raffaele, Via Olgettina 60, Milan, Italy.
Iran J Reprod Med. 2015 Jun;13(6):327-36.
Adenomyosis is a widespread disease affecting the reproductive period of women's life. In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease. This article aims to present and discuss the most important pathophysiologic mechanisms underlying adenomyosis development in order to clarify the relationship between adenomyosis and infertility. A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'. Although the exact etiology of adenomyosis is unknown, many theories have been proposed. We analysed the most important pathogenic theories expressed and evaluated the potential consequences on women fertility. A better comprehension of the adenomyosis pathogenesis has allowed realizing that adenomyosis may affect young women and may have a great impact on their fertility through different mechanisms. The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.
子宫腺肌病是一种影响女性生育期的常见疾病。在过去十年中，人们提出了不同的发病机制假说来解释该疾病的发生和发展。本文旨在阐述和讨论子宫腺肌病发生发展的最重要病理生理机制，以阐明子宫腺肌病与不孕症之间的关系。我们使用医学主题词“子宫腺肌病”“不孕症”“治疗”和“发病机制”在PubMed上搜索英文文献。尽管子宫腺肌病的确切病因尚不清楚，但已经提出了许多理论。我们分析了已发表的最重要的致病理论，并评估了其对女性生育能力的潜在影响。对子宫腺肌病发病机制的更好理解使我们认识到，子宫腺肌病可能影响年轻女性，并可能通过不同机制对其生育能力产生重大影响。对这些机制的理解有助于阐明当前治疗方法的潜在效用。
