Zang Yi-Wen, Gu Xiao-Dong, Xiang Jian-Bin, Chen Zong-You
Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai 200040, China.
Int J Mol Sci. 2012 Nov 26;13(12):15784-800. doi: 10.3390/ijms131215784.
Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.
结直肠癌是世界上最常见的消化道恶性肿瘤之一。由于更新且更有效的全身治疗方法，结直肠癌患者的生存期可显著延长，脑转移的发生率也在增加。然而，关于结直肠癌脑转移的潜在机制知之甚少。在此，我们综述了结直肠癌脑转移中的肿瘤微环境和转移相关分子。进一步了解这些机制将有助于我们为结直肠癌脑转移患者提出更好的治疗策略，并提高他们的生活质量。
