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Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study.口服姜黄素治疗阿尔茨海默病:24 周随机、双盲、安慰剂对照研究的耐受性和疗效。
Alzheimers Res Ther. 2012 Oct 29;4(5):43. doi: 10.1186/alzrt146. eCollection 2012.
2
A combination extract of ginseng, epimedium, polygala, and tuber curcumae increases synaptophysin expression in APPV717I transgenic mice.人参、淫羊藿、远志和莪术的组合提取物可增加 APPV717I 转基因小鼠突触体素的表达。
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Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).石杉碱甲和哈伯因 X 可改善三转基因 AD 小鼠(3xTg-AD)的认知功能,并调节与阿尔茨海默病相关的某些神经化学过程。
Neurodegener Dis. 2013;11(3):129-40. doi: 10.1159/000336427. Epub 2012 May 24.
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Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.细胞内亚淀粉样-β的积累减少,线粒体功能得到改善,介导了石杉碱甲的神经保护作用。
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PLoS One. 2012;7(1):e29641. doi: 10.1371/journal.pone.0029641. Epub 2012 Jan 3.
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Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment.计算证据表明,醉茄内酯 A 可抑制人乙酰胆碱酯酶,用于治疗阿尔茨海默病。
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Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trial.银杏叶提取物 EGb 761® 每日 1 次给药治疗阿尔茨海默病和血管性痴呆的疗效和耐受性:一项随机对照试验的结果。
Pharmacopsychiatry. 2012 Mar;45(2):41-6. doi: 10.1055/s-0031-1291217. Epub 2011 Nov 15.
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Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.石杉碱甲可减轻 APPswe/PS1dE9 转基因小鼠的突触缺陷,并调节淀粉样蛋白生成和非淀粉样蛋白生成途径。
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A phase II trial of huperzine A in mild to moderate Alzheimer disease.一项石杉碱甲治疗轻中度阿尔茨海默病的 II 期临床试验。
Neurology. 2011 Apr 19;76(16):1389-94. doi: 10.1212/WNL.0b013e318216eb7b.
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Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.石杉碱甲激活 Wnt/β-连环蛋白信号通路并增强阿尔茨海默病转基因小鼠模型中的非淀粉样蛋白生成途径。
Neuropsychopharmacology. 2011 Apr;36(5):1073-89. doi: 10.1038/npp.2010.245. Epub 2011 Feb 2.

中医:治疗老年痴呆症的有前景的候选者。

Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease.

机构信息

Department of Neurology, Henan Provincial People's Hospital, 450003, Zhengzhou, Henan Province, People's Republic of China.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 200025, Shanghai, People's Republic of China.

出版信息

Transl Neurodegener. 2013 Feb 28;2(1):6. doi: 10.1186/2047-9158-2-6.

DOI:10.1186/2047-9158-2-6
PMID:23445907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3599149/
Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and impairment of activities of daily living (ADL). Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, scientists have isolated many novel compounds from herbs, some of which improve dementia with fewer side effects than conventional drugs and are regarded as potential anti-AD drugs. In this review, we summarize the latest research progress on TCM showing their possible role of treatment of AD and other demented diseases and possible pharmacological actions.

摘要

阿尔茨海默病(AD)是一种与年龄相关的神经退行性疾病,临床上以隐匿性记忆和认知障碍、精神症状和行为障碍的出现以及日常生活活动(ADL)能力的损害为特征。中医药在中国医疗体系中已有 2000 多年的历史。近年来,科学家们从草药中分离出许多新型化合物,其中一些改善痴呆的药物比传统药物副作用更少,被认为是有潜力的抗 AD 药物。在这篇综述中,我们总结了中医药治疗 AD 和其他痴呆疾病的最新研究进展及其可能的药理作用。