Yata Nahoko, Uemura Osamu, Honda Masataka, Matsuyama Takeshi, Ishikura Kenji, Hataya Hiroshi, Nagai Takuhito, Ikezumi Yohei, Fujita Naoya, Ito Shuichi, Iijima Kazumoto, Saito Mari, Keneko Tetsuji, Kitagawa Teruo
The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan,
Clin Exp Nephrol. 2013 Dec;17(6):872-6. doi: 10.1007/s10157-013-0784-x. Epub 2013 Feb 28.
The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.
Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.
For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.
Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.
关于儿童胱抑素C参考范围的现有数据有限，且现有数据之间存在差异。本研究的目的是通过使用4种自动化检测方法来描述日本儿童胱抑素C的参考范围。
对1128名3个月至16岁无肾脏疾病的日本儿童测定血清胱抑素C水平。我们计算了年龄、性别、种族和检测方法特异性的胱抑素C范围。
对于所有4种检测方法，足月儿的血清胱抑素C中位数水平高于大龄儿童，并在出生后的前2年下降。血清胱抑素C中位数水平在14岁之前保持稳定，在15 - 16岁儿童中下降。12 - 16岁儿童中，男性血清胱抑素C中位数水平略高于女性。在所测血清胱抑素C水平中也观察到检测方法特异性差异。
年龄、性别、种族和检测方法特异性的血清胱抑素C范围应用作评估儿童肾功能的另一工具。
