Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Germany.
Eur Neuropsychopharmacol. 2013 Nov;23(11):1606-10. doi: 10.1016/j.euroneuro.2013.01.009. Epub 2013 Feb 27.
We carried out dynamic [(18)F]fallypride PET scans to measure cerebral dopamine D2/3 receptor availability in a 23-year old patient experiencing a severe withdrawal syndrome upon voluntary abstinence from "Spice", a pre-packaged herbal smoking thought to contain synthetic cannabinoids. Upon admission to the clinic, the patient experienced craving, affective symptoms and a range of somatic complaints, which resolved after several days' monitored abstinence. PET scans were performed on the day of admission, and one week later. Estimates of [(18)F]fallypride binding potential (BPND) were obtained in striatal and extrastriatal brain regions, and compared to results of age-matched healthy control subjects. Upon admission, [(18)F]fallypride BPND was reduced by 20% in the patient's striatum and also in extra-striatal regions. During short-term follow-up upon detoxification, the BPND increased to normal values. This study shows substantial short-term alterations of dopamine D2/3 receptor availability in a patient before and after acute detoxification from "Spice Gold", thus providing first evidence of reversible effects on dopamine receptors of heavy use of a herbal smoking blend.
我们进行了动态 [(18)F]fallypride PET 扫描，以测量一位 23 岁患者在自愿戒断“Spice”（一种预包装的草药吸烟产品，据信含有合成大麻素）后出现严重戒断综合征时大脑中多巴胺 D2/3 受体的可用性。患者入院时经历了渴望、情感症状和一系列躯体抱怨，这些症状在几天的监测性戒断后得到缓解。PET 扫描在入院当天和一周后进行。在纹状体和纹状体外脑区获得了 [(18)F]fallypride 结合潜能（BPND）的估计值，并与年龄匹配的健康对照组进行了比较。入院时，患者的纹状体和纹状体外区域的 [(18)F]fallypride BPND 降低了 20%。在短期随访期间，BPND 增加到正常水平。这项研究显示，在急性戒断“Spice Gold”前后，一位患者的多巴胺 D2/3 受体可用性发生了实质性的短期改变，从而首次提供了大量使用草药吸烟混合物对多巴胺受体产生可逆影响的证据。
