Hammer Daniel X, Ferguson R Daniel, Mujat Mircea, Patel Ankit, Plumb Emily, Iftimia Nicusor, Chui Toco Y P, Akula James D, Fulton Anne B
Physical Sciences Inc., 20 New England Business Center, Andover, Massachusetts 01810, USA.
J Opt Soc Am A Opt Image Sci Vis. 2012 Dec 1;29(12):2598-607. doi: 10.1364/JOSAA.29.002598.
Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are complementary imaging modalities, the combination of which can provide clinicians with a wealth of information to detect retinal diseases, monitor disease progression, or assess new therapies. Adaptive optics (AO) is a tool that enables correction of wavefront distortions from ocular aberrations. We have developed a multimodal adaptive optics system (MAOS) for high-resolution multifunctional use in a variety of research and clinical applications. The system integrates both OCT and SLO imaging channels into an AO beam path. The optics and hardware were designed with specific features for simultaneous SLO/OCT output, for high-fidelity AO correction, for use in humans, primates, and small animals, and for efficient location and orientation of retinal regions of interest. The MAOS system was tested on human subjects and rodents. The design, performance characterization, and initial representative results from the human and animal studies are presented and discussed.
光学相干断层扫描（OCT）和扫描激光检眼镜（SLO）是互补的成像方式，两者结合可为临床医生提供丰富信息，用于检测视网膜疾病、监测疾病进展或评估新疗法。自适应光学（AO）是一种能够校正眼像差引起的波前畸变的工具。我们开发了一种多模态自适应光学系统（MAOS），用于在各种研究和临床应用中进行高分辨率多功能使用。该系统将OCT和SLO成像通道集成到AO光束路径中。光学器件和硬件的设计具有特定功能，可实现SLO/OCT同步输出、高保真AO校正、适用于人类、灵长类动物和小动物，以及高效定位和确定视网膜感兴趣区域的方向。MAOS系统已在人类受试者和啮齿动物身上进行了测试。本文介绍并讨论了该系统的设计、性能表征以及来自人类和动物研究的初步代表性结果。
