Aging Research Laboratory, Korea Institute of Oriental Medicine, Daejeon, Korea.
Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):84-9. doi: 10.1111/phpp.12030.
Mangifera indica L. (Anacardiaceae) is a medicinal plant whose extracts have been described as an antioxidant with anti-inflammatory and immunomodulatory activities.
Skin aging is a consequence of chronic sun exposure to the sun and therefore ultraviolet (UV) radiation. Naturally occurring antioxidants are known to reduce skin aging. Therefore, the aim of the present study was to evaluate the protective role of mango extract against UVB-induced skin aging in hairless mice.
HR-1 hairless male mice (6 weeks old) were divided into three groups: control (n = 5), UVB-treated vehicle (n = 5), and UVB-treated mango extract (n = 5) groups. UVB-irradiated mice from the mango extract group were orally administered 0.1 ml of water containing 100 mg of mango extract/kg body weight per day. The inhibitory activity of mango extract on wrinkle formation was determined by the analysis of the skin replica, epidermal thickness based on histological examination, and damage to collagen fiber.
The mean length of wrinkles in UVB-treated vehicle group significantly improved after the oral administration of mango extract, which significantly inhibited the increase in epidermal thickness and epidermal hypertrophy (P < 0.05). Furthermore, a marked increase in collagen bundles was observed in the UVB-treated group after the administration of mango extract by Masson's trichrome staining.
These results indicate that mango extract showed anti-photoaging activity in UVB-irradiated hairless mice.
芒果（漆树科）是一种药用植物，其提取物具有抗氧化、抗炎和免疫调节作用。
皮肤衰老的一个后果是长期暴露在阳光下，尤其是紫外线（UV）辐射下。众所周知，天然存在的抗氧化剂可以减少皮肤衰老。因此，本研究旨在评估芒果提取物对无毛小鼠 UVB 诱导皮肤衰老的保护作用。
将 6 周龄 HR-1 无毛雄性小鼠分为三组：对照组（n = 5）、UVB 处理的载体组（n = 5）和 UVB 处理的芒果提取物组（n = 5）。芒果提取物组的 UVB 照射小鼠每天口服 0.1ml 含 100mg/kg 芒果提取物的水。通过皮肤复制品分析、基于组织学检查的表皮厚度和胶原纤维损伤来确定芒果提取物对皱纹形成的抑制活性。
与 UVB 处理的载体组相比，芒果提取物处理后 UVB 处理的载体组的皱纹平均长度显著改善，显著抑制了表皮厚度和表皮肥大的增加（P < 0.05）。此外，通过 Masson 三色染色，在芒果提取物给药后，UVB 处理组中的胶原束明显增加。
这些结果表明，芒果提取物在 UVB 照射的无毛小鼠中表现出抗光老化活性。
