National Institute of Traumatology and Orthopedics, Rio de Janeiro, Brazil.
Implant Dent. 2013 Apr;22(2):143-50. doi: 10.1097/ID.0b013e3182818792.
To analyze the interleukin (IL)-1β and IL-10 expressions in periimplant crevicular fluid (PICF) in healthy and diseased regions to elucidate the inflammatory process around implants and its influence on clinical diagnosis.
PICF samples from 30 patients were analyzed for IL-1β and IL-10 concentrations by enzyme-linked immunosorbent assay. Patients were divided in Groups A (health), B (mucositis), and C (periimplantitis). Plaque accumulation, periodontal phenotype (PP), depth on probing, and history of periodontitis (HP) were evaluated.
IL-1β levels were lower in healthy group compared with Groups B (P < 0.0005) and C (P < 0.001). IL-10 levels were higher in Groups A compared with B (P = 0.033) and C (P = 0.0001). Patients with HP and thin PP had 9 and 4.5 times more chance of presenting disease, respectively.
Lower IL-1β and higher IL-10 levels characterized healthy periimplant conditions, which demonstrate the anti-inflammatory predominance in sites without disease signs. IL-10 levels decrease significantly according to increase of disease status. Therefore, its levels can differentiate healthy, mucositis, and periimplantitis. Thin PP and HP are associated with periimplant disease. These findings suggest the use of ILs as a biochemical marker for early diagnosis of periimplant disease.
分析健康和患病种植体周围组织液（PICF）中的白细胞介素（IL）-1β和 IL-10 表达，以阐明种植体周围的炎症过程及其对临床诊断的影响。
通过酶联免疫吸附试验分析 30 名患者的 PICF 样本中 IL-1β 和 IL-10 浓度。患者分为 A 组（健康）、B 组（黏膜炎）和 C 组（种植体周围炎）。评估菌斑积聚、牙周表型（PP）、探诊深度和牙周炎病史（HP）。
与 B 组（P<0.0005）和 C 组（P<0.001）相比，健康组的 IL-1β 水平较低。与 B 组（P=0.033）和 C 组（P=0.0001）相比，A 组的 IL-10 水平较高。有 HP 和薄 PP 的患者分别有 9 倍和 4.5 倍的机会出现疾病。
较低的 IL-1β 和较高的 IL-10 水平特征性地描述了健康的种植体周围状况，这表明在没有疾病迹象的部位存在抗炎优势。随着疾病状态的增加，IL-10 水平显著降低。因此，其水平可以区分健康、黏膜炎和种植体周围炎。薄 PP 和 HP 与种植体周围疾病相关。这些发现表明，ILs 可作为种植体周围疾病早期诊断的生化标志物。
