Education Department at Instituto de Geriatría, México DF.
J Nutr Health Aging. 2013 Mar;17(3):259-62. doi: 10.1007/s12603-012-0434-0.
Sarcopenia has an important impact in elderly. Recently the European Working Group on Sarcopenia in Older People (EWGSOP) defined sarcopenia as the loss of muscle mass plus low muscle strength or low physical performance. Lack of clinical sounding outcomes (ie external validity), is one of the flaws of this algorithm. The aim of our study was to determine the association of sarcopenia and mortality in a group of Mexican elderly. A total of 345 elderly were recruited in Mexico City, and followed up for three years. The EWGSOP algorithm was integrated by: gait speed, grip strength and calf circumference. Other covariates were assessed in order to test the independent association of sarcopenia with mortality. Of the 345 subjects, 53.3% were women; with a mean age of 78.5 (SD 7) years. During the three year follow-up a total of 43 (12.4%) subjects died. Age, cognition, ADL, IADL, health self-perception, ischemic heart disease and sarcopenia were associated in the bivariate analysis with survival. Negative predictive value for sarcopenia regarding mortality was of 90%. Kaplan-Meier curves along with their respective log-rank test were significant for sarcopenia. The components of the final Cox-regression multivariate model were age, ischemic heart disease, ADL and sarcopenia. Adjusted HR for age was 3.24 (CI 95% 1.55-6.78 p 0.002), IHD 5.07 (CI 95% 1.89-13.59 p 0.001), health self-perception 5.07 (CI 95% 1.9-13.6 p 0.001), ADL 0.75 (CI 95% 0.56-0.99 p 0.048) and sarcopenia 2.39 (CI 95% 1.05-5.43 p 0.037).
肌少症对老年人有重要影响。最近，欧洲老年人肌少症工作组（EWGSOP）将肌少症定义为肌肉质量减少加上肌肉力量低下或身体机能低下。该算法的一个缺陷是缺乏临床相关结果（即外部有效性）。我们的研究目的是确定肌少症与墨西哥一组老年人死亡率之间的关系。在墨西哥城共招募了 345 名老年人，并进行了为期三年的随访。EWGSOP 算法通过：步态速度、握力和小腿围来整合。评估了其他协变量，以测试肌少症与死亡率的独立相关性。在 345 名受试者中，53.3%为女性；平均年龄为 78.5（SD 7）岁。在三年的随访期间，共有 43 名（12.4%）受试者死亡。年龄、认知、ADL、IADL、健康自我感知、缺血性心脏病和肌少症在单变量分析中与生存相关。肌少症对死亡率的阴性预测值为 90%。肌少症的 Kaplan-Meier 曲线及其各自的对数秩检验具有显著性。最终 Cox 回归多变量模型的组成部分是年龄、缺血性心脏病、ADL 和肌少症。年龄的调整后的 HR 为 3.24（95%CI 1.55-6.78 p 0.002），缺血性心脏病为 5.07（95%CI 1.89-13.59 p 0.001），健康自我感知为 5.07（95%CI 1.9-13.6 p 0.001），ADL 为 0.75（95%CI 0.56-0.99 p 0.048），肌少症为 2.39（95%CI 1.05-5.43 p 0.037）。
