Noble K G
Department of Ophthalmology, New York University Medical Center, New York 10016.
Am J Ophthalmol. 1990 Jun 15;109(6):656-60. doi: 10.1016/s0002-9394(14)72433-x.
Three siblings (a sister and two identical-twin brothers) had bilateral choroidal osteomas. The sister was seen at 11 years of age, and the tumor showed significant growth two years later. The twin brothers' tumors were diagnosed at 9 years of age, and their conditions remained stable over two years except for a new, isolated lesion that occurred in one eye of one brother. The siblings' mother had a yellow mottling situated nasal to the disk in each eye that was similar in appearance to that in one eye of one of the twins. She showed no evidence of calcium on ultrasonography. The appearance of osteomas in three siblings suggests a choristoma as the cause of this tumor.
三名兄弟姐妹（一名姐姐和两名同卵双胞胎兄弟）患有双侧脉络膜骨瘤。姐姐11岁时被发现患病，两年后肿瘤有显著生长。双胞胎兄弟的肿瘤在9岁时被诊断出来，除了其中一名兄弟一只眼睛出现一个新的孤立病变外，他们的病情在两年内保持稳定。这些兄弟姐妹的母亲每只眼睛的视盘鼻侧都有黄色斑纹，其外观与其中一名双胞胎兄弟一只眼睛的斑纹相似。超声检查未显示她有钙质沉积迹象。三名兄弟姐妹都出现骨瘤表明迷芽瘤是这种肿瘤的病因。
