Christ B, Poelmann R E, Mentink M M, Gittenberger-de Groot A C
Department of Developmental Biology, Ruhr-University Bochum, Federal Republic of Germany.
Anat Embryol (Berl). 1990;181(4):333-9. doi: 10.1007/BF00186905.
Migration of vascular endothelial cells was traced in quail-chick chimeras. After heterospecific transplantations of quail limb bud pieces, or other tissues containing blood vessels, into the limbs or the coelomic cavity, the immunohistochemically stained endothelial cells of the quail were found to invade the chick host vessels, favouring the arteries. Within these vessels the endothelial cells regularly reach the host aorta, where they contribute to the endothelium on the ipsilateral side. It is concluded that the endothelial cells activity migrate, because microinjections of a synthetic peptide which contains the RGD-sequence and mimics fibronectin, stop the invasion of endothelial cells.
在鹌鹑-鸡嵌合体中追踪血管内皮细胞的迁移。将鹌鹑肢体芽块或其他含有血管的组织异种移植到鸡的肢体或体腔后，发现经免疫组织化学染色的鹌鹑内皮细胞侵入鸡宿主血管，且更倾向于侵入动脉。在这些血管内，内皮细胞通常会到达宿主主动脉，并在同侧为内皮做出贡献。得出的结论是内皮细胞具有迁移活性，因为注射含有RGD序列并模拟纤连蛋白的合成肽会阻止内皮细胞的侵入。
