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通过自上而下的细胞膜涂层方法对纳米颗粒进行“自我标记”功能化。

'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach.

机构信息

Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

出版信息

Nanoscale. 2013 Apr 7;5(7):2664-8. doi: 10.1039/c3nr00015j.

DOI:10.1039/c3nr00015j
PMID:23462967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667603/
Abstract

We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.

摘要

我们通过天然 RBC 膜的涂层来研究纳米粒子的“自我标记”功能化。事实证明，这种膜转位方法非常高效，并赋予纳米粒子以正确定向和功能化的免疫调节蛋白，如 CD47，其密度与天然 RBC 相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/0d67d1651088/nihms452698f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/28eff22dcc94/nihms452698f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/2540fb022f43/nihms452698f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/1ba84856f148/nihms452698f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/0d67d1651088/nihms452698f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/28eff22dcc94/nihms452698f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/2540fb022f43/nihms452698f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/1ba84856f148/nihms452698f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f9/3667603/0d67d1651088/nihms452698f4.jpg

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