Department of Speech, Language, and Hearing Sciences, Boston University, Boston, Massachusetts 02215, USA.
J Acoust Soc Am. 2013 Mar;133(3):1637-43. doi: 10.1121/1.4776207.
The relative fundamental frequency (RFF) surrounding production of a voiceless consonant has previously been shown to be lower in speakers with hypokinetic dysarthria and Parkinson's disease (PD) relative to age/sex matched controls. Here RFF was calculated in 32 speakers with PD without overt hypokinetic dysarthria and 32 age and sex matched controls to better understand the relationships between RFF and PD progression, medication status, and sex. Results showed that RFF was statistically significantly lower in individuals with PD compared with healthy age-matched controls and was statistically significantly lower in individuals diagnosed at least 5 yrs prior to experimentation relative to individuals recorded less than 5 yrs past diagnosis. Contrary to previous trends, no effect of medication was found. However, a statistically significant effect of sex on offset RFF was shown, with lower values in males relative to females. Future work examining the physiological bases of RFF is warranted.
先前的研究表明，在患有运动迟缓性构音障碍和帕金森病（PD）的患者中，产生清音辅音时的相对基频（RFF）相对较低。在这里，计算了 32 名无明显运动迟缓性构音障碍的 PD 患者和 32 名年龄和性别匹配的对照组的 RFF，以更好地了解 RFF 与 PD 进展、药物状态和性别之间的关系。结果表明，与健康年龄匹配的对照组相比，PD 患者的 RFF 明显较低，与诊断至少 5 年前进行实验的患者相比，诊断时间少于 5 年的患者的 RFF 明显较低。与之前的趋势相反，未发现药物的影响。然而，发现了性别对起始 RFF 的统计学显著影响，男性的 RFF 值相对较低。未来需要进一步研究 RFF 的生理基础。
