Yale School of Medicine Child Study Center, 230 South Frontage Road, New Haven, CT, 06519, USA,
J Autism Dev Disord. 2013 Oct;43(10):2435-41. doi: 10.1007/s10803-013-1793-z.
Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.
许多患有广泛性发育障碍（PDD）的儿童表现出注意力缺陷/多动障碍（ADHD）的行为和症状。我们试图通过确定所有双盲、随机、安慰剂对照试验，来确定治疗 PDD 儿童 ADHD 症状的药物的相对疗效，这些试验检查了治疗 PDD 儿童 ADHD 症状的药物的疗效。我们找到了涉及 225 名儿童的七项试验。对四项哌醋甲酯试验的随机效应荟萃分析表明，哌醋甲酯对治疗 PDD 儿童的 ADHD 症状有效（ES=0.67）。与服用安慰剂的儿童相比，服用哌醋甲酯的儿童出现了几种不良事件。一项可乐定的单独试验和两项托莫西汀的试验表明，这些药物也可能对治疗 PDD 儿童的 ADHD 症状有效。
