Department of Medical Informatics, Kennedy Krieger Institute, 3825 Greenspring Avenue, Painter Building, 1st Floor, Baltimore, MD, 21211, USA.
J Autism Dev Disord. 2010 Mar;40(3):342-51. doi: 10.1007/s10803-009-0878-1.
Patterns of current psychotropic medication use among 5,181 children with autism spectrum disorders (ASD) enrolled in a Web-based registry were examined. Overall, 35% used at least one psychotropic medication, most commonly stimulants, neuroleptics, and/or antidepressants. Those who were uninsured or exclusively privately insured were less likely to use >or=3 medications than were those insured by Medicaid. Psychiatrists and neurologists prescribed the majority of psychotropic medications. In multivariate analysis, older age, presence of intellectual disability or psychiatric comorbidity, and residing in a poorer county or in the South or Midwest regions of the United States increased the odds of psychotropic medication use. Factors external to clinical presentation likely affect odds of psychotropic medication use among children with ASD.
研究人员调查了在一个基于网络的注册系统中登记的 5181 名自闭症谱系障碍(ASD)儿童中当前精神药物使用模式。总体而言,35%的儿童使用了至少一种精神药物,最常见的是兴奋剂、神经阻滞剂和/或抗抑郁药。未参保或仅私人保险的儿童比 Medicaid 保险的儿童更不可能使用≥3 种药物。精神科医生和神经科医生开了大多数精神药物。在多变量分析中,年龄较大、存在智力残疾或精神共病、居住在较贫困的县或美国南部或中西部地区会增加使用精神药物的几率。临床表型以外的因素可能会影响 ASD 儿童使用精神药物的几率。