Centre International de Recherche en Agronomie pour le Développement, UMR CMAEE, Montpellier, France.
PLoS One. 2013;8(2):e57509. doi: 10.1371/journal.pone.0057509. Epub 2013 Feb 28.
A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4(+) T lymphocytes. Moreover, CD62L expression indicated that both CD4(+) effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
更好地了解 T1 疫苗如何引发免疫，将有助于合理设计针对传染性牛胸膜肺炎（CBPP）的改良疫苗。我们在这里表明，在接受多次 T1 疫苗接种的牛中，可以检测到支原体诱导的回忆性增殖和 IFN-γ 反应。这些回忆性反应受到 CD4(+)T 淋巴细胞的严格控制。此外，CD62L 的表达表明，在这些动物中，既诱导了 CD4(+)效应记忆 (Tem) 和中央记忆 (Tcm)T 淋巴细胞。与从 CBPP 感染中完全康复的牛的数据进行比较分析表明，T1 疫苗接种动物存在类似的回忆性 T 细胞反应，尽管其反应幅度较低，尤其是在 Tcm 区室中。总之，我们讨论了我们对 T 细胞反应的当前理解将如何有助于正在进行的努力，以改善未来的 CBPP 疫苗。
