日本野桐果皮中细胞毒性成分的研究。IV。

Studies on cytotoxic constituents in pericarps of Mallotus japonicus. IV.

作者信息

Arisawa M, Fujita A, Hayashi T, Morita N, Kikuchi T, Tezuka Y

机构信息

Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Mar;38(3):698-700. doi: 10.1248/cpb.38.698.

DOI:10.1248/cpb.38.698

PMID:2347013

Abstract

Two new phloroglucinol derivatives, isomallotolerin (1) and isomallotochromanol (2), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-methy l-6- methoxybenzyl)-phlorisobutyrophenone (1) and 6-acetyl-5,7-dihydroxy-8-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzy l)-2,2- dimethyl-3-hydroxychroman (2) from chemical and spectral data. Isomallotolerin and its acetate were found to be cytotoxic to KB cell line.

摘要

从日本野桐果皮的细胞毒性组分中分离出两种新的间苯三酚衍生物，异棉皮苷（1）和异棉皮色原烷（2）。根据化学和光谱数据，新衍生物被鉴定为3-(3-甲基-2-羟基丁-3-烯基)-5-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-间苯异丁酰苯（1）和6-乙酰基-5,7-二羟基-8-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-2,2-二甲基-3-羟基色满（2）。发现异棉皮苷及其乙酸酯对KB细胞系具有细胞毒性。