Arisawa M, Fujita A, Saga M, Hayashi T, Morita N, Kawano N, Koshimura S
J Nat Prod. 1986 Mar-Apr;49(2):298-302. doi: 10.1021/np50044a016.
Two new phloroglucinol derivatives, mallotolerin (8) and mallotochromanol (9), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-me thy l-6- methoxybenxyl)-phlorbutyrophenone (8) and 8-acetyl-5,7-dihydroxy-6-(3-acetyl-2,4-dihydroxy-5-methyl-6- methoxybenxyl)2,2-dimethyl-3-hydroxychroman (9) by their respective chemical and spectral data. These compounds were found to be cytotoxic against KB and L-5178Y cell lines in culture and to be moderately effective in inhibiting the growth of Ehrlich carcinoma in mice. Cytotoxic activities of the isolated phloroglucinol derivatives (1-9) from the pericarps are also discussed.
从日本野桐果皮的细胞毒性部分中分离出两种新的间苯三酚衍生物，异叶野桐素（8）和野桐色满醇（9）。通过各自的化学和光谱数据，将这两种新衍生物鉴定为3-(3-甲基-2-羟基丁-3-烯基)-5-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-间苯丁酰苯（8）和8-乙酰基-5,7-二羟基-6-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-2,2-二甲基-3-羟基色满（9）。发现这些化合物对培养中的KB和L-5178Y细胞系具有细胞毒性，并且在抑制小鼠艾氏癌生长方面具有中等效果。还讨论了从果皮中分离出的间苯三酚衍生物（1-9）的细胞毒性活性。
