日本野桐果皮细胞毒性成分的研究，第一部分。

Studies on cytotoxic constituents in pericarps of Mallotus japonicus, Part I.

作者信息

Arisawa M, Fujita A, Suzuki R, Hayashi T, Morita N, Kawano N, Koshimura S

出版信息

J Nat Prod. 1985 May-Jun;48(3):455-9. doi: 10.1021/np50039a014.

Abstract

Two new phloroglucinol derivatives, named mallotophenone and mallotochromene, were isolated from the pericarps of Mallotus japonicus together with two known compounds, 3-(3,3-dimethylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6- methoxybenzyl)-phloracetophenone and 2,6-dihydroxy-3-methyl-4-methoxyacetophenone. The new derivatives were confirmed to be 5-methylene-bis-2,6-dihydroxy-3-methyl-4-methoxyacetophenone and 8-acetyl-5,7-dihydroxy-6-(3-acetyl-2,4-dihydroxy-5-methyl-6- methoxybenzyl)2,2-dimethylchromene by their respective chemical and spectral data. Several of the phloroglucinol derivatives isolated from this tree were cytotoxic against the KB system and L-5178Y in cell culture.

摘要

从日本野桐的果皮中分离出两种新的间苯三酚衍生物，分别命名为野桐苯醌和野桐色烯，同时还分离出两种已知化合物，即3-(3,3-二甲基烯丙基)-5-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-间苯三酚乙酮和2,6-二羟基-3-甲基-4-甲氧基苯乙酮。通过各自的化学和光谱数据证实，这两种新衍生物分别为5-亚甲基-双-2,6-二羟基-3-甲基-4-甲氧基苯乙酮和8-乙酰基-5,7-二羟基-6-(3-乙酰基-2,4-二羟基-5-甲基-6-甲氧基苄基)-2,2-二甲基色烯。从该植物中分离出的几种间苯三酚衍生物在细胞培养中对KB细胞系和L-5178Y细胞具有细胞毒性。