Fujita A, Hayashi T, Arisawa M, Shimizu M, Morita N, Kikuchi T, Tezuka Y
Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
J Nat Prod. 1988 Jul-Aug;51(4):708-12. doi: 10.1021/np50058a007.
Two new cytotoxic chromene derivatives, butyrylmallotochromene [10] and isobutyrylmallotochromene [11], were isolated from the pericarps of Mallotus japonicus. The new derivatives were identified as 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - butyryl-2,2-dimethylchromene [10] and 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - isobutyryl-2,2-dimethylchromene [11] by means of spectral data. These compounds and their respective acetylation and methylation products were found to be cytotoxic against KB cell lines.
从日本野桐的果皮中分离出两种新的细胞毒性色烯衍生物，丁酰野桐色烯[10]和异丁酰野桐色烯[11]。通过光谱数据将新衍生物鉴定为5,7-二羟基-6-(2',4'-二羟基-3'-乙酰基-5'-甲基-6'-甲氧基苄基)-8-丁酰基-2,2-二甲基色烯[10]和5,7-二羟基-6-(2',4'-二羟基-3'-乙酰基-5'-甲基-6'-甲氧基苄基)-8-异丁酰基-2,2-二甲基色烯[11]。发现这些化合物及其各自的乙酰化和甲基化产物对KB细胞系具有细胞毒性。
