日本野桐果皮中细胞毒性成分的研究，第三部分。

Studies on cytotoxic constituents in pericarps of Mallotus japonicus, Part III.

作者信息

Fujita A, Hayashi T, Arisawa M, Shimizu M, Morita N, Kikuchi T, Tezuka Y

机构信息

Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

J Nat Prod. 1988 Jul-Aug;51(4):708-12. doi: 10.1021/np50058a007.

DOI:10.1021/np50058a007

PMID:3210017

Abstract

Two new cytotoxic chromene derivatives, butyrylmallotochromene [10] and isobutyrylmallotochromene [11], were isolated from the pericarps of Mallotus japonicus. The new derivatives were identified as 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - butyryl-2,2-dimethylchromene [10] and 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - isobutyryl-2,2-dimethylchromene [11] by means of spectral data. These compounds and their respective acetylation and methylation products were found to be cytotoxic against KB cell lines.

摘要

从日本野桐的果皮中分离出两种新的细胞毒性色烯衍生物，丁酰野桐色烯[10]和异丁酰野桐色烯[11]。通过光谱数据将新衍生物鉴定为5,7-二羟基-6-(2',4'-二羟基-3'-乙酰基-5'-甲基-6'-甲氧基苄基)-8-丁酰基-2,2-二甲基色烯[10]和5,7-二羟基-6-(2',4'-二羟基-3'-乙酰基-5'-甲基-6'-甲氧基苄基)-8-异丁酰基-2,2-二甲基色烯[11]。发现这些化合物及其各自的乙酰化和甲基化产物对KB细胞系具有细胞毒性。