Phytochemical Profiling and Isolation of Bioactive Compounds from (Rosaceae).

In the study, ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry analysis of leaf and stem extracts led to the identification of various classes of compounds. Further chromatographic purifications resulted in the isolation of 22 compounds that consisted of a new triterpenoid named leucosidic acid A (), an acetophenone derivative , a phloroglucinol derivative , three chromones , seven pentacyclic triterpenoids , a phytosterol glucoside , a flavonoid , and seven flavonoid glycosides . Nineteen of these compounds including the previously undescribed triterpenoid are isolated for the first time from . The structures of the isolated compounds were assigned based on their high-resolution mass spectrometry and nuclear magnetic resonance data. Some of the isolated triterpenoids were evaluated for inhibitory activity against α-amylase, α-glucosidase, and pancreatic lipase. Of the tested compounds, 1-hydroxy-2-oxopomolic acid () and pomolic acid () showed higher potency on α-glucosidase than acarbose, which is used as a positive control in this study. The two compounds inhibited α-glucosidase with IC values of 192.1 ± 13.81 and 85.5 ± 6.87 μM, respectively.