Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.
Trends Immunol. 2013 Jun;34(6):269-81. doi: 10.1016/j.it.2013.02.002. Epub 2013 Mar 7.
Antigen stimulation of T cell receptor (TCR) signaling to nuclear factor (NF)-κB is required for T cell proliferation and differentiation of effector cells. The TCR-to-NF-κB pathway is generally viewed as a linear sequence of events in which TCR engagement triggers a cytoplasmic cascade of protein-protein interactions and post-translational modifications, ultimately culminating in the nuclear translocation of NF-κB. However, recent findings suggest a more complex picture in which distinct signalosomes, previously unrecognized proteins, and newly identified regulatory mechanisms play key roles in signal transmission. In this review, we evaluate recent data and suggest areas of future emphasis in the study of this important pathway.
T 细胞受体 (TCR) 信号向核因子 (NF)-κB 的抗原刺激是 T 细胞增殖和效应细胞分化所必需的。TCR 到 NF-κB 的途径通常被视为一系列线性事件，其中 TCR 结合触发细胞质蛋白-蛋白相互作用和翻译后修饰的级联反应，最终导致 NF-κB 的核易位。然而，最近的发现表明，在这个信号转导过程中，不同的信号小体、以前未被识别的蛋白质和新发现的调节机制起着关键作用，情况更为复杂。在这篇综述中，我们评估了最近的数据，并提出了在研究这个重要途径时未来需要关注的重点领域。
