Sadeghi Saman, Liang Vincent, Cheung Shilin, Woo Suh, Wu Curtis, Ly Jimmy, Deng Yuliang, Eddings Mark, van Dam R Michael
Crump Institute for Molecular Imaging and Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Appl Radiat Isot. 2013 May;75:85-94. doi: 10.1016/j.apradiso.2012.12.021. Epub 2013 Feb 13.
A brass-platinum electrochemical micro-flow cell was developed to extract [(18)F]fluoride from an aqueous solution and release it into an organic-based solution, suitable for subsequent radio-synthesis, in a fast and reliable manner. This cell does not suffer electrode erosion and is thus reusable while operating faster by enabling increased voltages. By optimizing temperature, trapping and release potentials, flow rates, and electrode materials, an overall [(18)F]fluoride trapping and release efficiency of 84 ± 5% (n=7) was achieved. X-ray photoelectron spectroscopy (XPS) was used to analyze electrode surfaces of various metal-metal systems and the findings were correlated with the performance of the electrochemical cell. To demonstrate the reactivity of the released [(18)F]fluoride, the cell was coupled to a flow-through reactor and automated synthesis of [(18)F]FDG with a repeatable decay-corrected yield of 56 ± 4% (n=4) was completed in < 15 min. A multi-human dose of 5.92GBq [(18)F]FDG was also demonstrated.
开发了一种铜-铂电化学微流池，用于从水溶液中提取[¹⁸F]氟化物，并将其快速可靠地释放到适用于后续放射性合成的有机基溶液中。该微流池不会出现电极腐蚀问题，因此可重复使用，并且通过提高电压能够更快地运行。通过优化温度、捕获和释放电位、流速以及电极材料，实现了[¹⁸F]氟化物的总体捕获和释放效率为84±5%（n=7）。使用X射线光电子能谱（XPS）分析了各种金属-金属系统的电极表面，并将结果与电化学微流池的性能相关联。为了证明释放出的[¹⁸F]氟化物的反应活性，将该微流池与流通式反应器相连，并在不到15分钟的时间内完成了[¹⁸F]FDG的自动化合成，经衰减校正后的可重复产率为56±4%（n=4）。还展示了5.92GBq的多人体剂量[¹⁸F]FDG。
