在用于¹⁸F标记放射性药物放射性合成的一次性微流控池中，通过电化学方法从[¹⁸O]水中浓缩无载体添加的[¹⁸F]氟化物。
Electrochemical concentration of no-carrier-added [(18)F]fluoride from [(18)O]water in a disposable microfluidic cell for radiosynthesis of (18)F-labeled radiopharmaceuticals.
作者信息
Saiki Hidekazu, Iwata Ren, Nakanishi Hiroaki, Wong Rebecca, Ishikawa Yoichi, Furumoto Shozo, Yamahara Ryo, Sakamoto Katsumasa, Ozeki Eiichi
机构信息
Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
出版信息
Appl Radiat Isot. 2010 Sep;68(9):1703-8. doi: 10.1016/j.apradiso.2010.02.005. Epub 2010 Feb 13.
The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [(18)F]fluoride was introduced into a disposable microfluidic cell (16microL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO(3) (ca. 60microL) under heat and a reversed potential (-2.5V). An automated module provided the [(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.
本文描述了一种用于微流控放射性合成的电化学方法，该方法可将无载体添加的[¹⁸F]氟化物水溶液浓缩到一次性微流控池中，转移至非质子溶剂中。在10V的电势下，将流动的[¹⁸F]氟化物水溶液引入一次性微流控池（16微升），随后加入无水乙腈。捕获的[¹⁸F]氟化物在加热和反向电势（-2.5V）下，在含有穴醚222-碳酸氢钾（约60微升）的乙腈中释放。一个自动化模块提供了可供后续微流控放射性合成的[¹⁸F]氟化物，在6分钟内总放射化学产率为60%。
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