Saiki Hidekazu, Iwata Ren, Nakanishi Hiroaki, Wong Rebecca, Ishikawa Yoichi, Furumoto Shozo, Yamahara Ryo, Sakamoto Katsumasa, Ozeki Eiichi
Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Appl Radiat Isot. 2010 Sep;68(9):1703-8. doi: 10.1016/j.apradiso.2010.02.005. Epub 2010 Feb 13.
The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [(18)F]fluoride was introduced into a disposable microfluidic cell (16microL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO(3) (ca. 60microL) under heat and a reversed potential (-2.5V). An automated module provided the [(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.
本文描述了一种用于微流控放射性合成的电化学方法，该方法可将无载体添加的[¹⁸F]氟化物水溶液浓缩到一次性微流控池中，转移至非质子溶剂中。在10V的电势下，将流动的[¹⁸F]氟化物水溶液引入一次性微流控池（16微升），随后加入无水乙腈。捕获的[¹⁸F]氟化物在加热和反向电势（-2.5V）下，在含有穴醚222-碳酸氢钾（约60微升）的乙腈中释放。一个自动化模块提供了可供后续微流控放射性合成的[¹⁸F]氟化物，在6分钟内总放射化学产率为60%。
