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一种新型抗病毒药物三氮唑核苷:II期临床试验结果

[A new antiviral drug Triazavirin: results of phase II clinical trial].

作者信息

Kiselev O I, Deeva E G, Mel'nikova T I, Kozeletskaia K N, Kiselev A S, Rusinov V L, Charushin V N, Chupakhin O N

出版信息

Vopr Virusol. 2012 Nov-Dec;57(6):9-12.

Abstract

The results of the clinical trial testing the efficacy of a new anti-influenza drug Triazavirin are presented in this work. The data of the trial were gathered during the 2010 influenza season. The treatment with oral Triazavirin significantly reduced the duration of the main clinical symptoms of influenza (intoxication, fever, respiratory symptoms), decreased the incidence of the influenza-related complications and the use of symptomatic drugs. The re-isolation rate of the influenza A and B viruses was significantly lower in the patients who were using Triazavirin. The analysis of the clinical data showed that the optimal prescribed dosage was 250 mg 3 times a day.

摘要

本文展示了一项针对新型抗流感药物三氮唑核苷疗效的临床试验结果。该试验数据收集于2010年流感季节。口服三氮唑核苷治疗显著缩短了流感主要临床症状(中毒、发热、呼吸道症状)的持续时间,降低了流感相关并发症的发生率以及对症药物的使用。使用三氮唑核苷的患者中甲型和乙型流感病毒的再分离率显著更低。临床数据分析表明,最佳规定剂量为每日3次,每次250毫克。

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