Institut Universitaire de Pathologie/CHUV/UNIL, Rue du Bugnon 25, 1011 Lausanne, Switzerland.
Nanomedicine (Lond). 2013 Mar;8(3):449-67. doi: 10.2217/nnm.13.8.
This article reviews nanoparticulate-chemotherapeutic systems that have been developed for human therapy, considering the components of the nanoparticles, the therapeutic agents associated with the nanoparticles and the clinical indications these therapeutic nanoparticles have been developed for. In this evaluation we have put into perspective the types of nanomaterials and their therapeutic indications. We have reviewed the nanoparticulate-chemotherapeutic systems that have been published, approved and marketed and that are currently in clinical use. We have also analyzed the nanoparticulate-chemotherapeutic systems that are in clinical trials and under preclinical development.
本文综述了已开发用于人体治疗的纳米颗粒化疗系统，考虑了纳米颗粒的组成部分、与纳米颗粒相关的治疗剂以及这些治疗性纳米颗粒开发的临床适应证。在这项评估中，我们从纳米材料的类型及其治疗适应证的角度进行了分析。我们回顾了已发表、已批准和已上市并正在临床使用的纳米颗粒化疗系统，还分析了正在临床试验和临床前开发阶段的纳米颗粒化疗系统。
