School of Chemistry, University of Hyderabad, Hyderabad, India.
Org Lett. 2013 Apr 5;15(7):1638-41. doi: 10.1021/ol400411v. Epub 2013 Mar 11.
The Ru(II)-catalyzed intermolecular o-C-H amidation of arenes in N-benzoylated sulfoximine with sulfonyl azides is demonstrated. The reaction proceeds with broad substrate scope and tolerates various functional groups. Base hydrolysis of the amidation product provides the anthranilic acid derivatives and methylphenyl sulfoximine (MPS) directing group. This method is successfully employed for the synthesis of HMR 1766.
该文报道了 Ru(II)催化的 N-苯甲酰化亚砜亚胺与磺酰叠氮的芳基间 o-C-H 酰胺化反应。该反应具有广泛的底物范围，能够容忍各种官能团。酰胺化产物的碱水解提供了邻氨基苯甲酸衍生物和甲基苯基砜亚胺（MPS）导向基团。该方法成功地用于 HMR 1766 的合成。
