Pan Changduo, Abdukader Ablimit, Han Jie, Cheng Yixiang, Zhu Chengjian
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 (P.R. China); Wenzhou Institute of Industry & Science, Wenzhou 325000 (P.R. China).
Chemistry. 2014 Mar 24;20(13):3606-9. doi: 10.1002/chem.201304236. Epub 2014 Feb 25.
A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.
开发了一种钌催化的吲哚啉C-H键与磺酰叠氮的直接C7酰胺化反应。该方法可用于合成多种7-氨基取代的吲哚啉，这些吲哚啉在制药领域很有用。良好的官能团耐受性以及温和的反应条件是该方法的突出特点。
