State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China; Weifang Business Vocational College, Zhucheng, China.
J Appl Microbiol. 2013 Jun;114(6):1582-91. doi: 10.1111/jam.12188. Epub 2013 Apr 4.
To determine the effects of Lactobacillus fermentum I5007 on the redox state of piglets oxidatively stressed with diquat.
Twenty-four, 28-day-old barrows were used in a 2 × 2 factorial design experiment with the main effects being Lact. fermentum supplementation and diquat challenge. Half of the pigs (n = 12) were orally administered with 20 ml of a solution containing 10(8 ) CFU ml(-1) of Lact. fermentum each morning of the 21-day trial, while the remainder received saline. On day 8, these two groups were further subdivided so that half of the pigs in each group (n = 6) were intraperitoneally injected with 10 mg kg(-1) BW diquat, while the remainder received saline. The diquat-injected pigs had significantly poorer performance and increased levels of plasma cortisol, adrenaline, carbonyl and malondialdehyde. Lactobacillus fermentum supplementation significantly increased superoxide dismutase and glutathione and increased the ability to inhibit superoxide anion production in liver and muscle.
Lactobacillus fermentum improved the anti-oxidative defence system and alleviated damage caused by diquat.
Lactobacillus fermentum has the potential to alleviate oxidative stress and improve weaning pig performance.
确定发酵乳杆菌 I5007 对百草枯氧化应激仔猪氧化还原状态的影响。
采用 2×2 析因设计试验，24 头 28 日龄公猪为试验动物，主要处理因素为发酵乳杆菌的补充和百草枯的挑战。一半的猪（n=12）在 21 天试验的每天早晨口服含有 10（8）CFU/ml 发酵乳杆菌的 20ml 溶液，其余的猪则接受生理盐水。在第 8 天，这两组进一步细分，使每组的一半猪（n=6）腹膜内注射 10mg/kg BW 百草枯，其余的猪则接受生理盐水。百草枯注射的猪表现明显较差，血浆皮质醇、肾上腺素、羰基和丙二醛水平升高。发酵乳杆菌的补充显著增加了超氧化物歧化酶和谷胱甘肽的含量，并提高了肝脏和肌肉抑制超氧阴离子产生的能力。
发酵乳杆菌改善了抗氧化防御系统，减轻了百草枯引起的损伤。
发酵乳杆菌有可能缓解氧化应激，提高断奶仔猪的性能。
