认知主诉和遗忘型轻度认知障碍老年人的默认模式网络连接改变。
Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment.
机构信息
Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
J Alzheimers Dis. 2013;35(4):751-60. doi: 10.3233/JAD-130080.
Abstract
Default mode network (DMN) disruption has been reported in Alzheimer's disease (AD), yet the specific pattern of altered connectivity over the course of prodromal AD remains to be characterized. The aim of this study was to assess DMN connectivity in older adults with informant-verified cognitive complaints (CC) but normal neuropsychological performance compared to individuals with mild cognitive impairment (MCI) and healthy controls (HC). DMN maps were derived from resting-state fMRI using independent component analysis. Group comparisons of DMN connectivity were performed between older adults with MCI (n = 18), CC (n = 23), and HC (n = 16). Both CC and MCI showed decreased DMN connectivity in the right hippocampus compared to HC, with the CC group showing greater connectivity than MCI. These differences survived atrophy correction and correlated with cognitive performance. DMN connectivity appears sensitive to early prodromal neurodegenerative changes associated with AD, notably including pre-MCI individuals with cognitive complaints.
摘要
默认模式网络（DMN）中断在阿尔茨海默病（AD）中已有报道，但前驱 AD 过程中连接改变的具体模式仍有待描述。本研究旨在评估认知主诉但神经心理学表现正常的老年人（CC）与轻度认知障碍（MCI）和健康对照组（HC）之间 DMN 的连接。使用独立成分分析从静息态 fMRI 中得出 DMN 图谱。在 MCI（n = 18）、CC（n = 23）和 HC（n = 16）老年人之间进行 DMN 连接的组间比较。CC 和 MCI 组与 HC 相比，右侧海马体的 DMN 连接减少，CC 组的连接比 MCI 组更多。这些差异在经过萎缩校正后仍然存在，并与认知表现相关。DMN 连接似乎对 AD 相关的早期前驱神经退行性变化敏感，特别是包括有认知主诉的前 MCI 个体。
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