High-Resolution Silicon Photomultiplier Time-of-Flight Dedicated Head PET System for Clinical Brain Studies.

We acquired brain F-FDG and F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) and a conventional whole-body PET/CT (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. There were 18 subjects for the F-FDG PET study and 17 subjects for the F-flutemetamol PET study. F-FDG PET images were first obtained using wbPET, followed by dhPET. F-flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxelwise analysis, and SUV ratio (SUVR). All F-FDG and F-flutemetamol images acquired using dhPET were judged as visually better than those acquired using wbPET. The voxelwise analysis demonstrated that accumulations in the cerebellum, in the lateral occipital cortices, and around the central sulcus area in dhPET F-FDG images were lower than those in wbPET F-FDG images, whereas accumulations around the ventricle systems were higher in dhPET F-FDG images than those in wbPET F-FDG images. Accumulations in the cerebellar dentate nucleus, in the midbrain, in the lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET F-flutemetamol images than those in wbPET F-flutemetamol images. The mean cortical SUVRs of F-FDG and F-flutemetamol dhPET images were significantly higher than those of F-FDG and F-flutemetamol wbPET images, respectively. The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.