Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Japan;
Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital, Osakasayama, Japan; and.
J Nucl Med. 2023 Jan;64(1):153-158. doi: 10.2967/jnumed.122.264080. Epub 2022 Jul 7.
We acquired brain F-FDG and F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) and a conventional whole-body PET/CT (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. There were 18 subjects for the F-FDG PET study and 17 subjects for the F-flutemetamol PET study. F-FDG PET images were first obtained using wbPET, followed by dhPET. F-flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxelwise analysis, and SUV ratio (SUVR). All F-FDG and F-flutemetamol images acquired using dhPET were judged as visually better than those acquired using wbPET. The voxelwise analysis demonstrated that accumulations in the cerebellum, in the lateral occipital cortices, and around the central sulcus area in dhPET F-FDG images were lower than those in wbPET F-FDG images, whereas accumulations around the ventricle systems were higher in dhPET F-FDG images than those in wbPET F-FDG images. Accumulations in the cerebellar dentate nucleus, in the midbrain, in the lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET F-flutemetamol images than those in wbPET F-flutemetamol images. The mean cortical SUVRs of F-FDG and F-flutemetamol dhPET images were significantly higher than those of F-FDG and F-flutemetamol wbPET images, respectively. The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.
我们使用专门用于头部的飞行时间系统（dhPET）和常规的全身 PET/CT（wbPET）系统获得脑 F-FDG 和 F-flutemetamol PET 图像，并评估了 dhPET 相对于 wbPET 的临床优势。有 18 名受试者进行 F-FDG PET 研究，17 名受试者进行 F-flutemetamol PET 研究。F-FDG PET 图像首先使用 wbPET 获得，然后使用 dhPET 获得。F-flutemetamol PET 图像首先使用 wbPET 获得，然后使用 dhPET 获得。通过视觉检查、体素分析和 SUV 比值（SUVr）比较 dhPET 和 wbPET 获得的图像。使用 dhPET 获得的所有 F-FDG 和 F-flutemetamol 图像均被判断为视觉效果优于使用 wbPET 获得的图像。体素分析表明，dhPET F-FDG 图像中小脑、外侧枕叶皮质和中央沟区域的蓄积低于 wbPET F-FDG 图像，而 dhPET F-FDG 图像中脑室系统周围的蓄积高于 wbPET F-FDG 图像。dhPET 图像中小脑齿状核、中脑、外侧枕叶皮质和中央沟区域的蓄积低于 wbPET 图像，而 dhPET F-flutemetamol 图像中脑室系统周围的蓄积高于 wbPET F-flutemetamol 图像。F-FDG 和 F-flutemetamol dhPET 图像的皮质 SUVr 平均值明显高于 F-FDG 和 F-flutemetamol wbPET 图像。dhPET 图像的视觉检查质量和 SUVr 均优于 wbPET 图像。尽管 dhPET 和 wbPET 图像之间存在一些区域蓄积差异，但了解这种现象将使我们能够在临床实践中充分利用这种 dhPET 系统的特点。
