Director School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India +91 33 2429 8313 ; +91 33 2414 6046 ;
Expert Opin Drug Discov. 2009 May;4(5):545-76. doi: 10.1517/17460440902911433.
Several lead compounds have been developed from natural resources as hepatoprotective. The hepatotoxic nature of the drugs, industrial toxins and drug-induced hepatotoxicity has been recognized as the major problem associated with liver diseases. Natural products including herbs have great potential in treating liver disorders.
Botanicals have been used traditionally by herbalists and indigenous healers worldwide for several years for the prevention and treatment of liver disease and clinical research in this century has confirmed the efficacy of several plants in the treatment of liver disease. Many herbs used in several systems of alternative medicines have a long history of traditional use in revitalizing the liver and treating liver dysfunction and disease. Many of these herbs have been evaluated in clinical studies and are now being investigated phytochemically to understand their actions in a better way.
An attempt has been made through this article to review the most potential medicinal plants with pharmacologically established hepatoprotective activity. Further, this article highlights their phytochemical profile and finds the effective leads from natural resources for the desired therapeutic benefit.
已有几种从天然资源中开发出来的先导化合物作为保肝药。药物、工业毒素和药物诱导的肝毒性的肝毒性已被认为是与肝病相关的主要问题。包括草药在内的天然产物在治疗肝脏疾病方面有很大的潜力。
植物药在全世界的草药医生和土着治疗师中已经使用了多年，用于预防和治疗肝脏疾病，本世纪的临床研究已经证实了几种植物在治疗肝脏疾病方面的疗效。许多在几种替代医学体系中使用的草药在恢复肝脏活力和治疗肝功能障碍和疾病方面有着悠久的传统使用历史。许多这些草药已经在临床研究中进行了评估，现在正在进行植物化学研究，以便更好地了解它们的作用。
本文试图综述具有已建立的药理学保肝活性的最有潜力的药用植物。此外，本文还重点介绍了它们的植物化学特征，并从天然资源中寻找具有所需治疗效果的有效先导化合物。
