École d'orthophonie et d'audiologie, Université de Montréal and Centre de recherche, CHU Sainte-Justine, Canada.
Clin Neurophysiol. 2013 Jul;124(7):1439-47. doi: 10.1016/j.clinph.2013.01.016. Epub 2013 Feb 26.
The aim of the study was to investigate the neurophysiological responses in children with hearing loss.
Cortical auditory evoked potentials and Mismatch Negativity (MMN) Responses were recorded in 40 children, 9-12 years old: 12 with hearing loss, 12 with central auditory processing disorder (CAPD) and 16 with normal hearing. Passive oddball paradigms were used with nonverbal and verbal stimuli.
For P1, no significant group differences were observed. A significant reduction in N2 amplitude with all stimuli was observed in the group of children with hearing loss compared to the results of those with normal hearing. N2 results did not reveal any significant differences between the group of children with hearing loss and the children with CAPD. MMN amplitude indicated a trend toward larger MMN amplitude among the group of children with hearing loss compared to the value of those of children with CAPD.
Abnormal N2 characteristics could be a manifestation of a specific signature in children with hearing loss. This cortical response could be considered as a neurophysiologic marker of central auditory processing deficits in these children.
Results suggest maturational delays and/or deficits in central auditory processing in children with hearing loss.
本研究旨在探讨听力损失儿童的神经生理反应。
对 40 名 9-12 岁儿童进行了皮质听觉诱发电位和失匹配负波（MMN）反应的记录：12 名听力损失儿童、12 名中枢听觉处理障碍（CAPD）儿童和 16 名正常听力儿童。采用被动Oddball 范式，使用非言语和言语刺激。
对于 P1，未观察到组间有显著差异。与正常听力组相比，听力损失组所有刺激的 N2 振幅显著降低。N2 结果未显示听力损失组与 CAPD 组儿童之间有任何显著差异。MMN 振幅表明，与 CAPD 组儿童的 MMN 振幅值相比，听力损失组儿童的 MMN 振幅有增大的趋势。
异常 N2 特征可能是听力损失儿童特定特征的表现。这种皮质反应可被视为这些儿童中枢听觉处理缺陷的神经生理标志物。
结果表明，听力损失儿童存在中枢听觉处理的发育延迟和/或缺陷。
