Liu Guangmao, Zhou Jianye, Hu Shengshou, Sun Hansong, Chen Haibo, Zhang Yan, Luo Fuliang
Key Laboratory of the Cardiovascular Regenerative Medicine, Ministry of Health, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Feb;30(1):141-8.
The tip structure is one of the key factors to determine the performance of left ventricular assist device (LVAD) inflow cannulas. The tip structure influences the thrombosis, hemolysis in cannula and left ventricle and suction leading to obstruction in ventricle. We designed four kinds of inflow cannulas that had different tips and built the numerical models of the four historical used inflow cannulas inserted into the apex of left ventricle. We computed the hemodynamic characteristics of inflow cannulas insertion by Fluent software. We researched the backflow, turbulent flow and pressure distribution of the four inflow cannulas. The results showed that the trumpet tipped inflow cannula had smooth flow velocity distribution without backflow or low velocity flow. The trumpet tipped inflow cannula had the best blood compatibility characteristics. The trumpet structure could prevent obstruction. The caged tipped cannula had serious turbulent flow which could possibly cause thrombosis and the low pressure near left ventricle wall and easily lead to ventricle collapse. The trumpet tipped inflow cannula has the best blood compatibility and is difficult to be obstructed. The trumpet tipped inflow cannula is fit to long-term use LVAD.
尖端结构是决定左心室辅助装置（LVAD）流入插管性能的关键因素之一。尖端结构会影响血栓形成、插管及左心室内的溶血以及导致心室梗阻的吸力。我们设计了四种具有不同尖端的流入插管，并建立了四种历史上使用过的插入左心室心尖的流入插管的数值模型。我们通过Fluent软件计算了流入插管插入时的血流动力学特征。我们研究了这四种流入插管的回流、湍流和压力分布。结果表明，喇叭形尖端流入插管的流速分布平滑，无回流或低速血流。喇叭形尖端流入插管具有最佳的血液相容性特征。喇叭形结构可防止梗阻。笼形尖端插管有严重的湍流，这可能会导致血栓形成，且左心室壁附近压力低，容易导致心室塌陷。喇叭形尖端流入插管具有最佳的血液相容性且不易被阻塞。喇叭形尖端流入插管适合长期使用LVAD。
