Department of Periodontology, Catholic University Leuven, Leuven, Belgium.
J Clin Periodontol. 2013 May;40(5):505-13. doi: 10.1111/jcpe.12090. Epub 2013 Mar 13.
The aim of this study was to assess the efficacy of mouthrinses formulations in oral malodour.
MATERIAL & METHODS: This single-centre, double-blind, randomized, parallel group clinical trial compared the efficacy of Halita™ and meridol(®) with and without zinc lactate versus negative and positive control. Volunteers with confirmed oral malodour (18/group) rinsed with one mouthrinse during 7 days (15 ml, 2x/day for 1 min.). 15 min. after a first rinse (masking effect), and after 7 days (therapeutic effect) the change in organoleptic scores and level of sulphur compounds was recorded.
All rinses showed a masking effect (OLS 1 to 2 values reduced), only the rinses with antimicrobial ingredients showed a therapeutic effect (OLS 1 to 1.5 value less). The addition of zinc resulted in a more pronounced masking effect. Halita™ and meridol(®) with zinc showed the best therapeutic effect.
Although the masking effect of the rinses can be attributed partially to a dilution and the effect of aromas, the therapeutic effect should be linked to the anti-microbial action of active ingredients and counter action of zinc ions on VSC. A complete resolution of the unpleasant breath by additional mechanical intervention remains to be proven.
本研究旨在评估漱口水配方在口腔异味中的疗效。
这是一项单中心、双盲、随机、平行组临床试验，比较了 Halita ™ 和 meridol( ® )与含或不含乳酸锌与阴性和阳性对照的疗效。确认有口腔异味的志愿者（每组 18 人）在 7 天内用一种漱口水漱口（15ml，每天 2 次，每次 1 分钟）。第一次漱口后 15 分钟（掩蔽作用）和 7 天后（治疗效果），记录感官评分和硫化合物水平的变化。
所有漱口水均显示出掩蔽作用（OLS1 到 2 值降低），只有含抗菌成分的漱口水显示出治疗效果（OLS1 到 1.5 值降低）。添加锌可产生更明显的掩蔽作用。含锌的 Halita ™ 和 meridol( ® )显示出最佳的治疗效果。
尽管漱口水的掩蔽作用部分归因于稀释和香气的作用，但治疗效果应与有效成分的抗菌作用和锌离子对 VSC 的拮抗作用相关。通过额外的机械干预来完全解决口臭问题仍有待证明。
