转录因子 GATA-3 控制着 2 型先天淋巴细胞的细胞命运和维持。
The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.
机构信息
IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Germany.
出版信息
Immunity. 2012 Oct 19;37(4):634-48. doi: 10.1016/j.immuni.2012.06.020. Epub 2012 Oct 11.
Abstract
Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperreactivity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for RORγt(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates.
摘要
先天淋巴细胞 (ILCs) 存在于黏膜表面，控制着对肠道感染的免疫反应。2 型先天淋巴细胞 (ILC2s) 产生细胞因子，如 IL-5 和 IL-13，是抵御寄生虫感染免疫防御所必需的，并且参与气道高反应性的发病机制。在这里，我们研究了转录因子 GATA-3 对 ILC2 分化和维持的作用。我们表明，ILC2s 及其谱系特异性骨髓前体（ILC2Ps），如本文所确定的，其特征是连续高表达 GATA-3。对所有 ILC 中 GATA-3 进行临时缺失的小鼠分析表明，GATA-3 是 ILC2 分化和维持所必需的，但不是 RORγt(+) ILC 所必需的。因此，我们的数据表明 GATA-3 对于 ILC2 命运决定是必不可少的，并揭示了控制 ILC 和辅助性 T 细胞命运的转录程序之间的相似性。
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