Paterson C A, Pfister R R
Invest Ophthalmol. 1975 Mar;14(3):177-83.
Following application of 20 mul of 2 N sodium hydroxide to the rabbit cornea, the prostaglandin-like activity in the aqueous humor increased from undetectable levels to around 30 ng, per milliliter, a level which was sustained for up to 24 hours. This increase correlated with the previously reported sustained elevation of intraocular pressure following a 20 mul alkali burn. Pretreatment with aspirin or indomethacin virtually abolished the increase in intraocular pressure and elevation of prostaglandin-like activity in the aqueous humor following a 20 mul burn. Marked ocular hypotension following 50 mul and 100 mul sodium hydroxide burns correlated with very low prostaglandin-like activity in the aqueous humor. The low prostaglandin-like activity probably resulted from alkaline hydrolysis of aqueous prostaglandins and massive cellular death in iris and ciliary body tissues.
向兔角膜滴注20微升2N氢氧化钠后，房水中类前列腺素活性从检测不到的水平升至约30纳克/毫升，并维持24小时。这种升高与先前报道的20微升碱烧伤后眼压持续升高相关。阿司匹林或吲哚美辛预处理几乎消除了20微升烧伤后眼压的升高和房水中类前列腺素活性的升高。50微升和100微升氢氧化钠烧伤后出现明显的眼压过低，这与房水中极低的类前列腺素活性相关。房水中类前列腺素活性低可能是由于房水中前列腺素的碱水解以及虹膜和睫状体组织中大量细胞死亡所致。
